Hydrogenation of a 4-benzylpyridine derivative over supported precious metal catalysts

Research output: Article

5 Citations (Scopus)

Abstract

The heterogeneous catalytic hydrogenation of 4-(4-fluorobenzyl)pyridine resulted in 4-(4-fluorobenzyl)piperidine, an important and valuable pharmaceutical intermediate. The effects of solvents, temperature, catalytic metals and amount of catalyst on the conversion and the rate of the hydrogenation were investigated. Among the precious metal catalysts applied, the best result was obtained by using a rhodium on carbon catalyst. Palladium or platinum on carbon also showed high activities. This hydrogenation is a key step in an industrially feasible synthesis developed recently.

Original languageEnglish
Pages (from-to)249-253
Number of pages5
JournalApplied Catalysis A: General
Volume269
Issue number1-2
DOIs
Publication statusPublished - aug. 18 2004

ASJC Scopus subject areas

  • Catalysis
  • Process Chemistry and Technology

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