The humoral immune response was studied in various types of chronic liver diseases (chronic active hepatitis, chronic persistent hepatitis, cirrhosis of liver, fatty liver) in 69 patients on the basis of the globulin level, sedimentation rate, thymol turbidity test, serum levels of the 3 main immunoglobulins, antibacterial antibody titres and factors of autoantibody character. An enhanced humoral immune response was found to represent a common feature of chronic liver disease associated with mesenchymal reaction. The data referred to above, in particular the immunoglobulin and antibody levels, proved indicative of the presence or of the absence of a mesenchymal reaction. High antibody levels, especially for enteral bacteria, were found typical of chronic liver disease associated with a mesenchymal reaction, in opposition to nonenteral bacterial antibodies which remained practically unaffected. The presence of factors of autoantibody nature points to a probable involvement of autoimmune mechanisms.
|Number of pages||10|
|Journal||Acta medica Academiae Scientiarum Hungaricae|
|Publication status||Published - dec. 1 1973|
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