Humoral immunity in chronic liver disease

K. Simon, A. Patakfalvi, A. Par, Z. Miszlay

Research output: Article


The humoral immune response was studied in various types of chronic liver diseases (chronic active hepatitis, chronic persistent hepatitis, cirrhosis of liver, fatty liver) in 69 patients on the basis of the globulin level, sedimentation rate, thymol turbidity test, serum levels of the 3 main immunoglobulins, antibacterial antibody titres and factors of autoantibody character. An enhanced humoral immune response was found to represent a common feature of chronic liver disease associated with mesenchymal reaction. The data referred to above, in particular the immunoglobulin and antibody levels, proved indicative of the presence or of the absence of a mesenchymal reaction. High antibody levels, especially for enteral bacteria, were found typical of chronic liver disease associated with a mesenchymal reaction, in opposition to nonenteral bacterial antibodies which remained practically unaffected. The presence of factors of autoantibody nature points to a probable involvement of autoimmune mechanisms.

Original languageEnglish
Pages (from-to)283-292
Number of pages10
JournalActa medica Academiae Scientiarum Hungaricae
Issue number4
Publication statusPublished - dec. 1 1973


ASJC Scopus subject areas

  • Medicine(all)

Cite this

Simon, K., Patakfalvi, A., Par, A., & Miszlay, Z. (1973). Humoral immunity in chronic liver disease. Acta medica Academiae Scientiarum Hungaricae, 30(4), 283-292.