Human herpesvirus 8 in classic kaposi sarcoma

L. Kemény, Mária Kiss, R. Gyulai, Anna Sz Kenderessy, Éva Ádám, F. Nagy, A. Dobozy

Research output: Article

7 Citations (Scopus)

Abstract

Recent studies suggest the role of a new human herpesvirus (HHV8) in the pathogenesis of different forms of Kaposi sarcoma (KS). In the present work we investigated the presence of HHV8 sequences in KS tumour tissues from patient with classic KS. Since clear evidences point to the role of immune suppression in the development of AIDS-associated KS or patients receiving immunosuppressive therapy, immunological investigations were also performed. We could show a highly consequent association of HHV8 sequences with classic KS in the large series of patients supporting our previous findings that this virus might be in some way involved in the pathogenesis of this tumour. In addition, immunological examination of the patients revealed a mild decrease in the CD4 positive cell number, a significantly reduced CD4/CD8 ratio, a diminished PHA reactivity and leukocyte migration factor production of lymphocytes. The changes observed in the present study are similar, but much less pronounced than those may be observed in HIV infection.

Original languageEnglish
Pages (from-to)391-395
Number of pages5
JournalActa microbiologica et immunologica Hungarica
Volume43
Issue number4
Publication statusPublished - dec. 1 1996

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

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