HPLC separation of opium alkaloids on porous and non-porous stationary phases

L. Krenn, B. Boros, R. Ohmacht, L. Jelinek

Research output: Article

10 Citations (Scopus)

Abstract

A new reversed-phase (RP) HPLC method has been developed and validated for the separation of the main opium alkaloids morphine, codeine, thebaine, papaverine and noscapine on a non-porous (micropellicular) stationary phase. On this phase quantification of the compounds by internal standardization with brucine was achieved extremely rapidly, in ca 1.5 min, only. Thus, the analysis time for the opium alkaloids was approximately one tenth of that on porous stationary phases. Different opium samples were investigated using non-porous and porous packings. The correlation between the results was excellent.

Original languageEnglish
Pages (from-to)S175-S178
JournalChromatographia
Volume51
Issue number1
DOIs
Publication statusPublished - jan. 1 2000

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

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