A series of amino-alkylaryl-ether and thioether derivatives with local anesthetic activity was investigated in an IP-RP HPLC system. Good correlation was found between the retention (log k’) and octanol-water partition coefficient (log P), The values of the correlation coefficients gradually increased with the increasing concentration of the ion-pairing agent, sodium dodecyl sulfate (NaDS). This experience is interpreted by the similar interactions in the partition and chromatographic systems. The Alog k’ and Jfvalues generated from the log k’ and log P values of the compounds having basic nucleus, showed also a good correlation.
ASJC Scopus subject areas
- Molecular Medicine