HPLC analysis of K-48 concentration in plasma

H. Kalász, M. Y. Hasan, R. Sheen, K. Kuca, G. Petroianu, K. Ludányi, A. Gergely, K. Tekes

Research output: Article

46 Citations (Scopus)

Abstract

K-48 is a new oxime-type compound to be used as an enzyme reactivator in the treatment of exposure to organophosphorous compounds. Plasma concentration of K-48 can be determined using reversed-phase HPLC. Analysis using octyl silica stationary phase and ultraviolet-absorbance detection is fast and simple. K-48 displays a relatively high dose-normalized area under the curve as compared to pralidoxime, which might be beneficial for an antidote. After i.m. administration of 50 μmol K-48, the time course of the concentration can be approximated by a straight line between 15 and 120 min meaning the elimination follows zero-order kinetics.

Original languageEnglish
Pages (from-to)1062-1067
Number of pages6
JournalAnalytical and Bioanalytical Chemistry
Volume385
Issue number6
DOIs
Publication statusPublished - júl. 1 2006

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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