History of simple febrile seizures is associated with hippocampal abnormalities in adults

Tibor Auer, P. Barsi, Beata Bone, Anna Angyalosi, Mihaly Aradi, Csaba Szalay, Reka A. Horvath, N. Kovács, Gyula Kotek, A. Fogarasi, S. Komoly, Imre Janszky, Attila Schwarcz, J. Janszky

Research output: Article

26 Citations (Scopus)

Abstract

Background: It is unclear whether the hippocampal abnormality in temporal lobe epilepsy (TLE) is a consequence or the cause of afebrile or febrile seizures (FSs). We investigated whether hippocampal abnormalities are present in healthy adults >15 years after a simple FS. Methods: Eight healthy subjects (5 men) with a history of simple FS (FS+ group) and eight sex- and aged-matched control subjects (FS- group) were investigated by three MR methods: blinded visual inspection of the MRI pictures; automatic voxel-based volumetry; and T2 relaxation time measurements. Results: The mean total volume of the two hippocampi was 5.36 ± 1.33 cm3 in the FS+ group and 6.63 ± 1.46 cm3 in the FS- group (p = 0.069). The T2 values in the anterior part of the left hippocampus (p = 0.036) and in the middle part of the right hippocampus (p = 0.025) were elevated in the FS+ subjects. The mean volume of the right hippocampus was 3.05 ± 0.8 cm3 in the FS+ men and 4.05 ± 0.48 cm3 in the FS- men (p = 0.043). The mean total volume of the two hippocampi was 5.38 ± 1.4 cm3 in the FS+ men and 7.48 ± 1.14 cm3 in the FS- men (p = 0.043). There were three FS+ men in whom hippocampal abnormalities including hippocampal sclerosis (HS) and dysgenesis were observed on visual inspection. Conclusions: A history of simple FS in childhood can be associated with hippocampal abnormalities in adults. These abnormalities are probably more pronounced in men. Simple FS may not be as a benign event as previously thought. Our findings suggest that hippocampal abnormalities associated with FS are not necessarily epileptogenic.

Original languageEnglish
Pages (from-to)1562-1569
Number of pages8
JournalEpilepsia
Volume49
Issue number9
DOIs
Publication statusPublished - szept. 2008

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Febrile Seizures
Hippocampus
Temporal Lobe Epilepsy
Sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

History of simple febrile seizures is associated with hippocampal abnormalities in adults. / Auer, Tibor; Barsi, P.; Bone, Beata; Angyalosi, Anna; Aradi, Mihaly; Szalay, Csaba; Horvath, Reka A.; Kovács, N.; Kotek, Gyula; Fogarasi, A.; Komoly, S.; Janszky, Imre; Schwarcz, Attila; Janszky, J.

In: Epilepsia, Vol. 49, No. 9, 09.2008, p. 1562-1569.

Research output: Article

Auer, T, Barsi, P, Bone, B, Angyalosi, A, Aradi, M, Szalay, C, Horvath, RA, Kovács, N, Kotek, G, Fogarasi, A, Komoly, S, Janszky, I, Schwarcz, A & Janszky, J 2008, 'History of simple febrile seizures is associated with hippocampal abnormalities in adults', Epilepsia, vol. 49, no. 9, pp. 1562-1569. https://doi.org/10.1111/j.1528-1167.2008.01679.x
Auer, Tibor ; Barsi, P. ; Bone, Beata ; Angyalosi, Anna ; Aradi, Mihaly ; Szalay, Csaba ; Horvath, Reka A. ; Kovács, N. ; Kotek, Gyula ; Fogarasi, A. ; Komoly, S. ; Janszky, Imre ; Schwarcz, Attila ; Janszky, J. / History of simple febrile seizures is associated with hippocampal abnormalities in adults. In: Epilepsia. 2008 ; Vol. 49, No. 9. pp. 1562-1569.
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abstract = "Background: It is unclear whether the hippocampal abnormality in temporal lobe epilepsy (TLE) is a consequence or the cause of afebrile or febrile seizures (FSs). We investigated whether hippocampal abnormalities are present in healthy adults >15 years after a simple FS. Methods: Eight healthy subjects (5 men) with a history of simple FS (FS+ group) and eight sex- and aged-matched control subjects (FS- group) were investigated by three MR methods: blinded visual inspection of the MRI pictures; automatic voxel-based volumetry; and T2 relaxation time measurements. Results: The mean total volume of the two hippocampi was 5.36 ± 1.33 cm3 in the FS+ group and 6.63 ± 1.46 cm3 in the FS- group (p = 0.069). The T2 values in the anterior part of the left hippocampus (p = 0.036) and in the middle part of the right hippocampus (p = 0.025) were elevated in the FS+ subjects. The mean volume of the right hippocampus was 3.05 ± 0.8 cm3 in the FS+ men and 4.05 ± 0.48 cm3 in the FS- men (p = 0.043). The mean total volume of the two hippocampi was 5.38 ± 1.4 cm3 in the FS+ men and 7.48 ± 1.14 cm3 in the FS- men (p = 0.043). There were three FS+ men in whom hippocampal abnormalities including hippocampal sclerosis (HS) and dysgenesis were observed on visual inspection. Conclusions: A history of simple FS in childhood can be associated with hippocampal abnormalities in adults. These abnormalities are probably more pronounced in men. Simple FS may not be as a benign event as previously thought. Our findings suggest that hippocampal abnormalities associated with FS are not necessarily epileptogenic.",
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T1 - History of simple febrile seizures is associated with hippocampal abnormalities in adults

AU - Auer, Tibor

AU - Barsi, P.

AU - Bone, Beata

AU - Angyalosi, Anna

AU - Aradi, Mihaly

AU - Szalay, Csaba

AU - Horvath, Reka A.

AU - Kovács, N.

AU - Kotek, Gyula

AU - Fogarasi, A.

AU - Komoly, S.

AU - Janszky, Imre

AU - Schwarcz, Attila

AU - Janszky, J.

PY - 2008/9

Y1 - 2008/9

N2 - Background: It is unclear whether the hippocampal abnormality in temporal lobe epilepsy (TLE) is a consequence or the cause of afebrile or febrile seizures (FSs). We investigated whether hippocampal abnormalities are present in healthy adults >15 years after a simple FS. Methods: Eight healthy subjects (5 men) with a history of simple FS (FS+ group) and eight sex- and aged-matched control subjects (FS- group) were investigated by three MR methods: blinded visual inspection of the MRI pictures; automatic voxel-based volumetry; and T2 relaxation time measurements. Results: The mean total volume of the two hippocampi was 5.36 ± 1.33 cm3 in the FS+ group and 6.63 ± 1.46 cm3 in the FS- group (p = 0.069). The T2 values in the anterior part of the left hippocampus (p = 0.036) and in the middle part of the right hippocampus (p = 0.025) were elevated in the FS+ subjects. The mean volume of the right hippocampus was 3.05 ± 0.8 cm3 in the FS+ men and 4.05 ± 0.48 cm3 in the FS- men (p = 0.043). The mean total volume of the two hippocampi was 5.38 ± 1.4 cm3 in the FS+ men and 7.48 ± 1.14 cm3 in the FS- men (p = 0.043). There were three FS+ men in whom hippocampal abnormalities including hippocampal sclerosis (HS) and dysgenesis were observed on visual inspection. Conclusions: A history of simple FS in childhood can be associated with hippocampal abnormalities in adults. These abnormalities are probably more pronounced in men. Simple FS may not be as a benign event as previously thought. Our findings suggest that hippocampal abnormalities associated with FS are not necessarily epileptogenic.

AB - Background: It is unclear whether the hippocampal abnormality in temporal lobe epilepsy (TLE) is a consequence or the cause of afebrile or febrile seizures (FSs). We investigated whether hippocampal abnormalities are present in healthy adults >15 years after a simple FS. Methods: Eight healthy subjects (5 men) with a history of simple FS (FS+ group) and eight sex- and aged-matched control subjects (FS- group) were investigated by three MR methods: blinded visual inspection of the MRI pictures; automatic voxel-based volumetry; and T2 relaxation time measurements. Results: The mean total volume of the two hippocampi was 5.36 ± 1.33 cm3 in the FS+ group and 6.63 ± 1.46 cm3 in the FS- group (p = 0.069). The T2 values in the anterior part of the left hippocampus (p = 0.036) and in the middle part of the right hippocampus (p = 0.025) were elevated in the FS+ subjects. The mean volume of the right hippocampus was 3.05 ± 0.8 cm3 in the FS+ men and 4.05 ± 0.48 cm3 in the FS- men (p = 0.043). The mean total volume of the two hippocampi was 5.38 ± 1.4 cm3 in the FS+ men and 7.48 ± 1.14 cm3 in the FS- men (p = 0.043). There were three FS+ men in whom hippocampal abnormalities including hippocampal sclerosis (HS) and dysgenesis were observed on visual inspection. Conclusions: A history of simple FS in childhood can be associated with hippocampal abnormalities in adults. These abnormalities are probably more pronounced in men. Simple FS may not be as a benign event as previously thought. Our findings suggest that hippocampal abnormalities associated with FS are not necessarily epileptogenic.

KW - Gender differences

KW - Hippocampal sclerosis

KW - Mesial temporal lobe epilepsy

KW - MRI volumetry

KW - Simple febrile convulsions

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