Abstract
Background: It is unclear whether the hippocampal abnormality in temporal lobe epilepsy (TLE) is a consequence or the cause of afebrile or febrile seizures (FSs). We investigated whether hippocampal abnormalities are present in healthy adults >15 years after a simple FS. Methods: Eight healthy subjects (5 men) with a history of simple FS (FS+ group) and eight sex- and aged-matched control subjects (FS- group) were investigated by three MR methods: blinded visual inspection of the MRI pictures; automatic voxel-based volumetry; and T2 relaxation time measurements. Results: The mean total volume of the two hippocampi was 5.36 ± 1.33 cm3 in the FS+ group and 6.63 ± 1.46 cm3 in the FS- group (p = 0.069). The T2 values in the anterior part of the left hippocampus (p = 0.036) and in the middle part of the right hippocampus (p = 0.025) were elevated in the FS+ subjects. The mean volume of the right hippocampus was 3.05 ± 0.8 cm3 in the FS+ men and 4.05 ± 0.48 cm3 in the FS- men (p = 0.043). The mean total volume of the two hippocampi was 5.38 ± 1.4 cm3 in the FS+ men and 7.48 ± 1.14 cm3 in the FS- men (p = 0.043). There were three FS+ men in whom hippocampal abnormalities including hippocampal sclerosis (HS) and dysgenesis were observed on visual inspection. Conclusions: A history of simple FS in childhood can be associated with hippocampal abnormalities in adults. These abnormalities are probably more pronounced in men. Simple FS may not be as a benign event as previously thought. Our findings suggest that hippocampal abnormalities associated with FS are not necessarily epileptogenic.
| Original language | English |
|---|---|
| Pages (from-to) | 1562-1569 |
| Number of pages | 8 |
| Journal | Epilepsia |
| Volume | 49 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - szept. 2008 |
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ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
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History of simple febrile seizures is associated with hippocampal abnormalities in adults. / Auer, Tibor; Barsi, P.; Bone, Beata; Angyalosi, Anna; Aradi, Mihaly; Szalay, Csaba; Horvath, Reka A.; Kovács, N.; Kotek, Gyula; Fogarasi, A.; Komoly, S.; Janszky, Imre; Schwarcz, Attila; Janszky, J.
In: Epilepsia, Vol. 49, No. 9, 09.2008, p. 1562-1569.Research output: Article
}
TY - JOUR
T1 - History of simple febrile seizures is associated with hippocampal abnormalities in adults
AU - Auer, Tibor
AU - Barsi, P.
AU - Bone, Beata
AU - Angyalosi, Anna
AU - Aradi, Mihaly
AU - Szalay, Csaba
AU - Horvath, Reka A.
AU - Kovács, N.
AU - Kotek, Gyula
AU - Fogarasi, A.
AU - Komoly, S.
AU - Janszky, Imre
AU - Schwarcz, Attila
AU - Janszky, J.
PY - 2008/9
Y1 - 2008/9
N2 - Background: It is unclear whether the hippocampal abnormality in temporal lobe epilepsy (TLE) is a consequence or the cause of afebrile or febrile seizures (FSs). We investigated whether hippocampal abnormalities are present in healthy adults >15 years after a simple FS. Methods: Eight healthy subjects (5 men) with a history of simple FS (FS+ group) and eight sex- and aged-matched control subjects (FS- group) were investigated by three MR methods: blinded visual inspection of the MRI pictures; automatic voxel-based volumetry; and T2 relaxation time measurements. Results: The mean total volume of the two hippocampi was 5.36 ± 1.33 cm3 in the FS+ group and 6.63 ± 1.46 cm3 in the FS- group (p = 0.069). The T2 values in the anterior part of the left hippocampus (p = 0.036) and in the middle part of the right hippocampus (p = 0.025) were elevated in the FS+ subjects. The mean volume of the right hippocampus was 3.05 ± 0.8 cm3 in the FS+ men and 4.05 ± 0.48 cm3 in the FS- men (p = 0.043). The mean total volume of the two hippocampi was 5.38 ± 1.4 cm3 in the FS+ men and 7.48 ± 1.14 cm3 in the FS- men (p = 0.043). There were three FS+ men in whom hippocampal abnormalities including hippocampal sclerosis (HS) and dysgenesis were observed on visual inspection. Conclusions: A history of simple FS in childhood can be associated with hippocampal abnormalities in adults. These abnormalities are probably more pronounced in men. Simple FS may not be as a benign event as previously thought. Our findings suggest that hippocampal abnormalities associated with FS are not necessarily epileptogenic.
AB - Background: It is unclear whether the hippocampal abnormality in temporal lobe epilepsy (TLE) is a consequence or the cause of afebrile or febrile seizures (FSs). We investigated whether hippocampal abnormalities are present in healthy adults >15 years after a simple FS. Methods: Eight healthy subjects (5 men) with a history of simple FS (FS+ group) and eight sex- and aged-matched control subjects (FS- group) were investigated by three MR methods: blinded visual inspection of the MRI pictures; automatic voxel-based volumetry; and T2 relaxation time measurements. Results: The mean total volume of the two hippocampi was 5.36 ± 1.33 cm3 in the FS+ group and 6.63 ± 1.46 cm3 in the FS- group (p = 0.069). The T2 values in the anterior part of the left hippocampus (p = 0.036) and in the middle part of the right hippocampus (p = 0.025) were elevated in the FS+ subjects. The mean volume of the right hippocampus was 3.05 ± 0.8 cm3 in the FS+ men and 4.05 ± 0.48 cm3 in the FS- men (p = 0.043). The mean total volume of the two hippocampi was 5.38 ± 1.4 cm3 in the FS+ men and 7.48 ± 1.14 cm3 in the FS- men (p = 0.043). There were three FS+ men in whom hippocampal abnormalities including hippocampal sclerosis (HS) and dysgenesis were observed on visual inspection. Conclusions: A history of simple FS in childhood can be associated with hippocampal abnormalities in adults. These abnormalities are probably more pronounced in men. Simple FS may not be as a benign event as previously thought. Our findings suggest that hippocampal abnormalities associated with FS are not necessarily epileptogenic.
KW - Gender differences
KW - Hippocampal sclerosis
KW - Mesial temporal lobe epilepsy
KW - MRI volumetry
KW - Simple febrile convulsions
UR - http://www.scopus.com/inward/record.url?scp=51249122590&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=51249122590&partnerID=8YFLogxK
U2 - 10.1111/j.1528-1167.2008.01679.x
DO - 10.1111/j.1528-1167.2008.01679.x
M3 - Article
C2 - 18503555
AN - SCOPUS:51249122590
VL - 49
SP - 1562
EP - 1569
JO - Epilepsia
JF - Epilepsia
SN - 0013-9580
IS - 9
ER -