Histamine treatment at neonatal age influences histamine production by peritoneal cells in adult rats

O. Torok, B. Kiss, J. Szeberenyi, Z. Radvany, A. Falus

Research output: Article

Abstract

Introduction: Histamine is one of the most important mediators in the mammalian organism. It has a basic role in numerous physiological functions and also in the regulation of cell growth. Material and methods: In the present study the level of cell-bound and secreted histamine was measured in rats exposed to histamine in vivo during their neonatal age or in controls. Results and main conclusions: The findings strongly suggest that the in vivo treatment of neonatal rats with histamine leads to significantly increased level of both spontaneous and histamine-provoked histamine secretion at the age of two months. The results suggest a long-lasting effect of neonatal histamine treatment.

Original languageEnglish
Pages (from-to)1055-1058
Number of pages4
JournalMedical Science Monitor
Volume5
Issue number6
Publication statusPublished - dec. 1 1999

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ASJC Scopus subject areas

  • Medicine(all)

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