Introduction: Histamine is one of the most important mediators in the mammalian organism. It has a basic role in numerous physiological functions and also in the regulation of cell growth. Material and methods: In the present study the level of cell-bound and secreted histamine was measured in rats exposed to histamine in vivo during their neonatal age or in controls. Results and main conclusions: The findings strongly suggest that the in vivo treatment of neonatal rats with histamine leads to significantly increased level of both spontaneous and histamine-provoked histamine secretion at the age of two months. The results suggest a long-lasting effect of neonatal histamine treatment.
|Number of pages||4|
|Journal||Medical Science Monitor|
|Publication status||Published - dec. 1 1999|
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