High prevalence of IgA class anti-neutrophil cytoplasmic antibodies (ANCA) is associated with increased risk of bacterial infection in patients with cirrhosis

M. Papp, Nora Sipeki, Zsuzsanna Vitalis, Tamas Tornai, I. Altorjay, Istvan Tornai, M. Udvardy, Kai Fechner, Silvia Jacobsen, Bianca Teegen, Andrea Sumegi, G. Verès, P. Lakatos, J. Kappelmayer, P. Antal-Szalmás

Research output: Article

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Abstract

Background & Aims Anti-neutrophil cytoplasmic antibodies (ANCA) are a non-uniform family of antibodies recognizing diverse components of neutrophil granulocytes. ANCA formation might be induced by protracted bacterial infections or probably reflect an abnormal immune response to commensal microorganisms. Bacterial infections are common complications in cirrhosis with high incidence of episodes caused by enteric organisms, therefore, we sought to study the presence and clinical importance of ANCA in cirrhosis. Methods Sera of 385 patients with cirrhosis of different etiologies were assayed for ANCA of IgG, IgA, IgA1, IgA2, and secretory IgA subtypes by indirect immunofluorescence and ELISAs. The control group comprised 202 patients with chronic liver diseases without cirrhosis and 100 healthy subjects. In cirrhosis, a 2-year follow-up, observational study was conducted to assess a possible association between the presence of ANCA and clinically significant bacterial infections. Results Prevalence of ANCA IgA was significantly higher in cirrhosis (52.2%) compared to chronic liver diseases (18.6%) or healthy controls (0%, p

Original languageEnglish
Pages (from-to)457-466
Number of pages10
JournalJournal of Hepatology
Volume59
Issue number3
DOIs
Publication statusPublished - szept. 2013

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Antineutrophil Cytoplasmic Antibodies
Bacterial Infections
Immunoglobulin A
Fibrosis
Liver Diseases
Chronic Disease
Secretory Immunoglobulin A
Indirect Fluorescent Antibody Technique
Granulocytes
Antibody Formation
Observational Studies
Healthy Volunteers
Neutrophils
Immunoglobulin G
Enzyme-Linked Immunosorbent Assay
Control Groups
Antibodies
Incidence
Serum

ASJC Scopus subject areas

  • Hepatology

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High prevalence of IgA class anti-neutrophil cytoplasmic antibodies (ANCA) is associated with increased risk of bacterial infection in patients with cirrhosis. / Papp, M.; Sipeki, Nora; Vitalis, Zsuzsanna; Tornai, Tamas; Altorjay, I.; Tornai, Istvan; Udvardy, M.; Fechner, Kai; Jacobsen, Silvia; Teegen, Bianca; Sumegi, Andrea; Verès, G.; Lakatos, P.; Kappelmayer, J.; Antal-Szalmás, P.

In: Journal of Hepatology, Vol. 59, No. 3, 09.2013, p. 457-466.

Research output: Article

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abstract = "Background & Aims Anti-neutrophil cytoplasmic antibodies (ANCA) are a non-uniform family of antibodies recognizing diverse components of neutrophil granulocytes. ANCA formation might be induced by protracted bacterial infections or probably reflect an abnormal immune response to commensal microorganisms. Bacterial infections are common complications in cirrhosis with high incidence of episodes caused by enteric organisms, therefore, we sought to study the presence and clinical importance of ANCA in cirrhosis. Methods Sera of 385 patients with cirrhosis of different etiologies were assayed for ANCA of IgG, IgA, IgA1, IgA2, and secretory IgA subtypes by indirect immunofluorescence and ELISAs. The control group comprised 202 patients with chronic liver diseases without cirrhosis and 100 healthy subjects. In cirrhosis, a 2-year follow-up, observational study was conducted to assess a possible association between the presence of ANCA and clinically significant bacterial infections. Results Prevalence of ANCA IgA was significantly higher in cirrhosis (52.2{\%}) compared to chronic liver diseases (18.6{\%}) or healthy controls (0{\%}, p",
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T1 - High prevalence of IgA class anti-neutrophil cytoplasmic antibodies (ANCA) is associated with increased risk of bacterial infection in patients with cirrhosis

AU - Papp, M.

AU - Sipeki, Nora

AU - Vitalis, Zsuzsanna

AU - Tornai, Tamas

AU - Altorjay, I.

AU - Tornai, Istvan

AU - Udvardy, M.

AU - Fechner, Kai

AU - Jacobsen, Silvia

AU - Teegen, Bianca

AU - Sumegi, Andrea

AU - Verès, G.

AU - Lakatos, P.

AU - Kappelmayer, J.

AU - Antal-Szalmás, P.

PY - 2013/9

Y1 - 2013/9

N2 - Background & Aims Anti-neutrophil cytoplasmic antibodies (ANCA) are a non-uniform family of antibodies recognizing diverse components of neutrophil granulocytes. ANCA formation might be induced by protracted bacterial infections or probably reflect an abnormal immune response to commensal microorganisms. Bacterial infections are common complications in cirrhosis with high incidence of episodes caused by enteric organisms, therefore, we sought to study the presence and clinical importance of ANCA in cirrhosis. Methods Sera of 385 patients with cirrhosis of different etiologies were assayed for ANCA of IgG, IgA, IgA1, IgA2, and secretory IgA subtypes by indirect immunofluorescence and ELISAs. The control group comprised 202 patients with chronic liver diseases without cirrhosis and 100 healthy subjects. In cirrhosis, a 2-year follow-up, observational study was conducted to assess a possible association between the presence of ANCA and clinically significant bacterial infections. Results Prevalence of ANCA IgA was significantly higher in cirrhosis (52.2%) compared to chronic liver diseases (18.6%) or healthy controls (0%, p

AB - Background & Aims Anti-neutrophil cytoplasmic antibodies (ANCA) are a non-uniform family of antibodies recognizing diverse components of neutrophil granulocytes. ANCA formation might be induced by protracted bacterial infections or probably reflect an abnormal immune response to commensal microorganisms. Bacterial infections are common complications in cirrhosis with high incidence of episodes caused by enteric organisms, therefore, we sought to study the presence and clinical importance of ANCA in cirrhosis. Methods Sera of 385 patients with cirrhosis of different etiologies were assayed for ANCA of IgG, IgA, IgA1, IgA2, and secretory IgA subtypes by indirect immunofluorescence and ELISAs. The control group comprised 202 patients with chronic liver diseases without cirrhosis and 100 healthy subjects. In cirrhosis, a 2-year follow-up, observational study was conducted to assess a possible association between the presence of ANCA and clinically significant bacterial infections. Results Prevalence of ANCA IgA was significantly higher in cirrhosis (52.2%) compared to chronic liver diseases (18.6%) or healthy controls (0%, p

KW - Anti-neutrophil cytoplasmic antibodies

KW - Bacterial infection

KW - Cirrhosis

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