Heterogeneous neuronal firing patterns during interictal epileptiform discharges in the human cortex

Corey J. Keller, Wilson Truccolo, John T. Gale, Emad Eskandar, Thomas Thesen, Chad Carlson, Orrin Devinsky, Ruben Kuzniecky, Werner K. Doyle, Joseph R. Madsen, Donald L. Schomer, Ashesh D. Mehta, Emery N. Brown, Leigh R. Hochberg, I. Ulbert, Eric Halgren, Sydney S. Cash

Research output: Article

90 Citations (Scopus)

Abstract

Epileptic cortex is characterized by paroxysmal electrical discharges. Analysis of these interictal discharges typically manifests as spike-wave complexes on electroencephalography, and plays a critical role in diagnosing and treating epilepsy. Despite their fundamental importance, little is known about the neurophysiological mechanisms generating these events in human focal epilepsy. Using three different systems of microelectrodes, we recorded local field potentials and single-unit action potentials during interictal discharges in patients with medically intractable focal epilepsy undergoing diagnostic workup for localization of seizure foci. We studied 336 single units in 20 patients. Ten different cortical areas and the hippocampus, including regions both inside and outside the seizure focus, were sampled. In three of these patients, high density microelectrode arrays simultaneously recorded between 43 and 166 single units from a small (4 mm × 4 mm) patch of cortex. We examined how the firing rates of individual neurons changed during interictal discharges by determining whether the firing rate during the event was the same, above or below a median baseline firing rate estimated from interictal discharge-free periods (Kruskal-Wallis one-way analysis, P

Original languageEnglish
Pages (from-to)1668-1681
Number of pages14
JournalBrain
Volume133
Issue number6
DOIs
Publication statusPublished - jún. 2010

Fingerprint

Partial Epilepsy
Microelectrodes
Seizures
Patient Discharge
Action Potentials
Electroencephalography
Epilepsy
Hippocampus
Neurons
Drug Resistant Epilepsy

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Keller, C. J., Truccolo, W., Gale, J. T., Eskandar, E., Thesen, T., Carlson, C., ... Cash, S. S. (2010). Heterogeneous neuronal firing patterns during interictal epileptiform discharges in the human cortex. Brain, 133(6), 1668-1681. https://doi.org/10.1093/brain/awq112

Heterogeneous neuronal firing patterns during interictal epileptiform discharges in the human cortex. / Keller, Corey J.; Truccolo, Wilson; Gale, John T.; Eskandar, Emad; Thesen, Thomas; Carlson, Chad; Devinsky, Orrin; Kuzniecky, Ruben; Doyle, Werner K.; Madsen, Joseph R.; Schomer, Donald L.; Mehta, Ashesh D.; Brown, Emery N.; Hochberg, Leigh R.; Ulbert, I.; Halgren, Eric; Cash, Sydney S.

In: Brain, Vol. 133, No. 6, 06.2010, p. 1668-1681.

Research output: Article

Keller, CJ, Truccolo, W, Gale, JT, Eskandar, E, Thesen, T, Carlson, C, Devinsky, O, Kuzniecky, R, Doyle, WK, Madsen, JR, Schomer, DL, Mehta, AD, Brown, EN, Hochberg, LR, Ulbert, I, Halgren, E & Cash, SS 2010, 'Heterogeneous neuronal firing patterns during interictal epileptiform discharges in the human cortex', Brain, vol. 133, no. 6, pp. 1668-1681. https://doi.org/10.1093/brain/awq112
Keller CJ, Truccolo W, Gale JT, Eskandar E, Thesen T, Carlson C et al. Heterogeneous neuronal firing patterns during interictal epileptiform discharges in the human cortex. Brain. 2010 jún.;133(6):1668-1681. https://doi.org/10.1093/brain/awq112
Keller, Corey J. ; Truccolo, Wilson ; Gale, John T. ; Eskandar, Emad ; Thesen, Thomas ; Carlson, Chad ; Devinsky, Orrin ; Kuzniecky, Ruben ; Doyle, Werner K. ; Madsen, Joseph R. ; Schomer, Donald L. ; Mehta, Ashesh D. ; Brown, Emery N. ; Hochberg, Leigh R. ; Ulbert, I. ; Halgren, Eric ; Cash, Sydney S. / Heterogeneous neuronal firing patterns during interictal epileptiform discharges in the human cortex. In: Brain. 2010 ; Vol. 133, No. 6. pp. 1668-1681.
@article{3425451b523b40399f08093d7ec0ad16,
title = "Heterogeneous neuronal firing patterns during interictal epileptiform discharges in the human cortex",
abstract = "Epileptic cortex is characterized by paroxysmal electrical discharges. Analysis of these interictal discharges typically manifests as spike-wave complexes on electroencephalography, and plays a critical role in diagnosing and treating epilepsy. Despite their fundamental importance, little is known about the neurophysiological mechanisms generating these events in human focal epilepsy. Using three different systems of microelectrodes, we recorded local field potentials and single-unit action potentials during interictal discharges in patients with medically intractable focal epilepsy undergoing diagnostic workup for localization of seizure foci. We studied 336 single units in 20 patients. Ten different cortical areas and the hippocampus, including regions both inside and outside the seizure focus, were sampled. In three of these patients, high density microelectrode arrays simultaneously recorded between 43 and 166 single units from a small (4 mm × 4 mm) patch of cortex. We examined how the firing rates of individual neurons changed during interictal discharges by determining whether the firing rate during the event was the same, above or below a median baseline firing rate estimated from interictal discharge-free periods (Kruskal-Wallis one-way analysis, P",
keywords = "Focal epilepsy, Microelectrodes, Microphysiology, Single unit, Spike-wave",
author = "Keller, {Corey J.} and Wilson Truccolo and Gale, {John T.} and Emad Eskandar and Thomas Thesen and Chad Carlson and Orrin Devinsky and Ruben Kuzniecky and Doyle, {Werner K.} and Madsen, {Joseph R.} and Schomer, {Donald L.} and Mehta, {Ashesh D.} and Brown, {Emery N.} and Hochberg, {Leigh R.} and I. Ulbert and Eric Halgren and Cash, {Sydney S.}",
year = "2010",
month = "6",
doi = "10.1093/brain/awq112",
language = "English",
volume = "133",
pages = "1668--1681",
journal = "Brain",
issn = "0006-8950",
publisher = "Oxford University Press",
number = "6",

}

TY - JOUR

T1 - Heterogeneous neuronal firing patterns during interictal epileptiform discharges in the human cortex

AU - Keller, Corey J.

AU - Truccolo, Wilson

AU - Gale, John T.

AU - Eskandar, Emad

AU - Thesen, Thomas

AU - Carlson, Chad

AU - Devinsky, Orrin

AU - Kuzniecky, Ruben

AU - Doyle, Werner K.

AU - Madsen, Joseph R.

AU - Schomer, Donald L.

AU - Mehta, Ashesh D.

AU - Brown, Emery N.

AU - Hochberg, Leigh R.

AU - Ulbert, I.

AU - Halgren, Eric

AU - Cash, Sydney S.

PY - 2010/6

Y1 - 2010/6

N2 - Epileptic cortex is characterized by paroxysmal electrical discharges. Analysis of these interictal discharges typically manifests as spike-wave complexes on electroencephalography, and plays a critical role in diagnosing and treating epilepsy. Despite their fundamental importance, little is known about the neurophysiological mechanisms generating these events in human focal epilepsy. Using three different systems of microelectrodes, we recorded local field potentials and single-unit action potentials during interictal discharges in patients with medically intractable focal epilepsy undergoing diagnostic workup for localization of seizure foci. We studied 336 single units in 20 patients. Ten different cortical areas and the hippocampus, including regions both inside and outside the seizure focus, were sampled. In three of these patients, high density microelectrode arrays simultaneously recorded between 43 and 166 single units from a small (4 mm × 4 mm) patch of cortex. We examined how the firing rates of individual neurons changed during interictal discharges by determining whether the firing rate during the event was the same, above or below a median baseline firing rate estimated from interictal discharge-free periods (Kruskal-Wallis one-way analysis, P

AB - Epileptic cortex is characterized by paroxysmal electrical discharges. Analysis of these interictal discharges typically manifests as spike-wave complexes on electroencephalography, and plays a critical role in diagnosing and treating epilepsy. Despite their fundamental importance, little is known about the neurophysiological mechanisms generating these events in human focal epilepsy. Using three different systems of microelectrodes, we recorded local field potentials and single-unit action potentials during interictal discharges in patients with medically intractable focal epilepsy undergoing diagnostic workup for localization of seizure foci. We studied 336 single units in 20 patients. Ten different cortical areas and the hippocampus, including regions both inside and outside the seizure focus, were sampled. In three of these patients, high density microelectrode arrays simultaneously recorded between 43 and 166 single units from a small (4 mm × 4 mm) patch of cortex. We examined how the firing rates of individual neurons changed during interictal discharges by determining whether the firing rate during the event was the same, above or below a median baseline firing rate estimated from interictal discharge-free periods (Kruskal-Wallis one-way analysis, P

KW - Focal epilepsy

KW - Microelectrodes

KW - Microphysiology

KW - Single unit

KW - Spike-wave

UR - http://www.scopus.com/inward/record.url?scp=77952988712&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952988712&partnerID=8YFLogxK

U2 - 10.1093/brain/awq112

DO - 10.1093/brain/awq112

M3 - Article

C2 - 20511283

AN - SCOPUS:77952988712

VL - 133

SP - 1668

EP - 1681

JO - Brain

JF - Brain

SN - 0006-8950

IS - 6

ER -