Heterogeneous Catalytic Hydrogenation of 3-Phenylpropionitrile over Palladium on Carbon

Krisztina Lévay, Kamilla Dóra Tóth, Tamás Kárpáti, László Hegedüs

Research output: Article

Abstract

A previously developed and industrially feasible process for selective, Pd-mediated, liquid-phase heterogeneous catalytic hydrogenation of nitriles to primary amines was extended to the reduction of 3-phenylpropionitrile (PPN) to 3-phenylpropylamine (PPA). PPN, which belongs to the homologous series of benzonitrile (BN) and benzyl cyanide (BC), was hydrogenated under mild reaction conditions (30-80 °C, 6 bar), over Pd/C, in two immiscible solvents (dichloromethane/water) and using acidic additives (NaH2PO4 and H2SO4). Although relatively high conversion (76%) was achieved, the selectivity to PPA (26%) and its isolated yield (20%) were lesser than those in the case of the hydrogenation of BN or BC reported earlier. However, the purity of PPA was >99% without using any purification method. Quantum chemical calculations using a density functional theory (DFT) method were performed to compare the adsorption interactions of the different imine intermediates on palladium, as well as to clarify the differences observed in the primary amine selectivity. PPA is a valuable intermediate for the synthesis of carboxypeptidase B enzyme inhibitors, antimuscarinic drugs, or potential anticancer agents in the pharmaceutical industry.

Original languageEnglish
Pages (from-to)5487-5497
Number of pages11
JournalACS Omega
Volume5
Issue number10
DOIs
Publication statusPublished - márc. 17 2020

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Fingerprint Dive into the research topics of 'Heterogeneous Catalytic Hydrogenation of 3-Phenylpropionitrile over Palladium on Carbon'. Together they form a unique fingerprint.

  • Cite this