Viral hepatitis caused by Hepatitis E Virus (HEV), an enterically transmitted human pathogen is mainly associated with acute, self-limited, icteric hepatitis with an average of 1% mortality. Animal reservoirs are suspected to play role in the maintenance of the virus and in the spread of HEV to humans, having account not only in food-hygiene but also in workplace health and safety. Although, up to now clinical hepatitis in animals has not been observed, HEV-induced seroconversion was described in several species. HEV strains of animal and human origins are genetically closely related, which supports the suspicion on the zoonotic transmission of the virus. In the authors' survey done between 2005 and 2009 the occurrence of HEV was investigated in samples of animal origin collected in Hungary. HEV RNA was detected by reverse transcription-polymerase chain reaction in liver and faeces samples of domestic swine belonging to different age groups, wild boar, red deer and roe deer. 11 % of samples of examined wild boars, 22% of samples of roe deer and 10% of samples of red deer were positive. Samples of domestic ruminants, as well as rodents and common shrew collected in swine farms, forests and meadows were tested negative for HEV RNA. Phylogenetic analysis of partial sequences of the viral nucleic acid of selected strains revealed that the investigated viruses belong to 3 subgroups of the third genogroup of HEV, and are closely related to HEV strains of human and animal origins detected in different countries. The investigations revealed widespread distribution of HEV in animals in Hungary, and considerable genetic diversity amongst the strains.
|Number of pages||12|
|Journal||Magyar Allatorvosok Lapja|
|Publication status||Published - 2010|
ASJC Scopus subject areas