A hepatitis e vírus - Irodalmi áttekintés és hazai helyzet állatorvos szemmel

Forgách Petra, Boncz Attila, Erdélyi Károly, Lorinez Marta, Molnár Beáta, Zentai János, Szucs Gyorgy, Reuter Gábor, Bakonyi Tamás

Research output: Review article

Abstract

Viral hepatitis caused by Hepatitis E Virus (HEV), an enterically transmitted human pathogen is mainly associated with acute, self-limited, icteric hepatitis with an average of 1% mortality. Animal reservoirs are suspected to play role in the maintenance of the virus and in the spread of HEV to humans, having account not only in food-hygiene but also in workplace health and safety. Although, up to now clinical hepatitis in animals has not been observed, HEV-induced seroconversion was described in several species. HEV strains of animal and human origins are genetically closely related, which supports the suspicion on the zoonotic transmission of the virus. In the authors' survey done between 2005 and 2009 the occurrence of HEV was investigated in samples of animal origin collected in Hungary. HEV RNA was detected by reverse transcription-polymerase chain reaction in liver and faeces samples of domestic swine belonging to different age groups, wild boar, red deer and roe deer. 11 % of samples of examined wild boars, 22% of samples of roe deer and 10% of samples of red deer were positive. Samples of domestic ruminants, as well as rodents and common shrew collected in swine farms, forests and meadows were tested negative for HEV RNA. Phylogenetic analysis of partial sequences of the viral nucleic acid of selected strains revealed that the investigated viruses belong to 3 subgroups of the third genogroup of HEV, and are closely related to HEV strains of human and animal origins detected in different countries. The investigations revealed widespread distribution of HEV in animals in Hungary, and considerable genetic diversity amongst the strains.

Original languageHungarian
Pages (from-to)237-248
Number of pages12
JournalMagyar Allatorvosok Lapja
Volume132
Issue number4
Publication statusPublished - 2010

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ASJC Scopus subject areas

  • veterinary(all)

Cite this

Petra, F., Attila, B., Károly, E., Marta, L., Beáta, M., János, Z., Gyorgy, S., Gábor, R., & Tamás, B. (2010). A hepatitis e vírus - Irodalmi áttekintés és hazai helyzet állatorvos szemmel. Magyar Allatorvosok Lapja, 132(4), 237-248.