Az N-acetilcisztein hemodinamikai hatása és ischaemiás prekondicionálás máj ischaemia-reperfúzió modellen

Subhamay Ghosh, János Baumann, Boglárka Falusi, Lajos Bogár, Erzsébet Roth, János Gál

Research output: Article

2 Citations (Scopus)

Abstract

The aim of the study was to investigate whether repeated ischemic preconditioning or N-acetylcystein (NAC) prevents ischemic-reperfusion injury as determined by having favourable hemodynamic effects during reperfusion in canine livers. Methods: The control group (n = 10) underwent 60 minutes of hepatic ischemia followed by 180 minutes reperfusion. In the NAC group (n = 5) 150 mg kg-1 of NAC was administered intravenously before inducing ischemia. In the preconditioned group (n = 5) animals received ischemic preconditioning (10 minutes of ischemia followed by 10 minutes of reperfusion repeated three times) before clamping the portal triad. Results: 18 dogs survived the study period. One dog in the NAC group died due to circulatory failure unresponsive to inotropic drugs. The cardiac index and the intrathoracic blood volume index were significantly higher in the preconditioning group compared to the controls throughout the study period. Conclusions: Repeated ischemic preconditioning might improve hemodynamic parameters, whereas we were unable to find any significant differences between the groups regarding N-acetylcystein.

Translated title of the contributionHemodynamic effects of N-acetylcystein and ischemic preconditioning in a liver ischemia-reperfusion model
Original languageHungarian
Pages (from-to)2245-2249
Number of pages5
JournalOrvosi hetilap
Volume149
Issue number47
DOIs
Publication statusPublished - nov. 23 2008

Keywords

  • Hemodynamics
  • Ischemia-reperfusion
  • N-acetylcystein
  • Preconditioning

ASJC Scopus subject areas

  • Medicine(all)

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