Helix and H-bond formations of alanine-based peptides containing basic amino acids

Balázs Leitgeb, Gábor Janzsó, Liza Hudoba, B. Penke, G. Rákhely, F. Bogár

Research output: Article

4 Citations (Scopus)

Abstract

We studied comprehensively the helicity and H-bonding evolutions during the folding processes of Lysand Arg-containing alanine-based peptides. The evolution of a-helical conformation concerning the entire sequence and each amino acid residue was examined, as well as the helix-forming propensities were characterized. The formation of various types of the intramolecular H-bonds was also investigated, pointing out the helix-stabilizing role of local interactions and the destabilizing role of non-local interplays. Our study led to the observation that the nonlocal H-bonds affected the evolution of helical conformations, as well as the entire folding processes.

Original languageEnglish
Pages (from-to)1287-1295
Number of pages9
JournalStructural Chemistry
Volume22
Issue number6
DOIs
Publication statusPublished - dec. 2011

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Basic Amino Acids
alanine
Alanine
helices
peptides
amino acids
Conformations
folding
Peptides
Amino Acids
interactions

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

Cite this

Helix and H-bond formations of alanine-based peptides containing basic amino acids. / Leitgeb, Balázs; Janzsó, Gábor; Hudoba, Liza; Penke, B.; Rákhely, G.; Bogár, F.

In: Structural Chemistry, Vol. 22, No. 6, 12.2011, p. 1287-1295.

Research output: Article

Leitgeb, Balázs ; Janzsó, Gábor ; Hudoba, Liza ; Penke, B. ; Rákhely, G. ; Bogár, F. / Helix and H-bond formations of alanine-based peptides containing basic amino acids. In: Structural Chemistry. 2011 ; Vol. 22, No. 6. pp. 1287-1295.
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