Harnessing the Versatility of Continuous-Flow Processes: Selective and Efficient Reactions

I. Mándity, Sándor B. Ötvös, György Szőlősi, F. Fülöp

Research output: Article

32 Citations (Scopus)

Abstract

There is a great need for effective transformations and a broad range of novel chemical entities. Continuous-flow (CF) approaches are of considerable current interest: highly efficient and selective reactions can be performed in CF reactors. The reaction setup of CF reactors offers a wide variety of possible points where versatility can be introduced. This article presents a number of selective and highly efficient gas–liquid–solid and liquid–solid reactions involving a range of reagents and immobilized catalysts. Enantioselective transformations through catalytic hydrogenation and organocatalytic reactions are included, and isotopically labelled compounds and pharmaceutically relevant 1,2,3-triazoles are synthesized in CF reactors. Importantly, the catalyst bed can be changed to a solid-phase peptide synthesis resin, with which peptide synthesis can be performed with the utilization of only 1.5 equivalents of the amino acid. (Figure presented.).

Original languageEnglish
Pages (from-to)1018-1033
Number of pages16
JournalChemical Record
DOIs
Publication statusPublished - jún. 1 2016

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Solid-Phase Synthesis Techniques
Triazoles
Hydrogenation
Peptides
Amino Acids
Catalysts
Amino acids
Resins

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Materials Chemistry
  • Biochemistry
  • Biochemistry, medical

Cite this

Harnessing the Versatility of Continuous-Flow Processes : Selective and Efficient Reactions. / Mándity, I.; Ötvös, Sándor B.; Szőlősi, György; Fülöp, F.

In: Chemical Record, 01.06.2016, p. 1018-1033.

Research output: Article

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