Haptoglobin polimorfizmus vizsgálata gyulladásos bélbetegségekben

M. Papp, P. Lakatos, P. Fuszek, S. Fischer, F. Szalay, János Osztovics, Henrik Csaba Horvath, P. Vargha, L. Bene, J. Lonovics, F. Nagy, Levente Bálint, Ferenc Huoranszky, István Dobó, Z. Tulassay, L. Herszényi, P. Miheller, A. Németh, György Székely, Z. ErdélyiG. Mester, Csaba Molnár, T. Pandúr, K. Palatka, Ildikó Földi, M. Udvardy, J. Hársfalvi, István Tornai, Zuszsanna Vitális, Tamás Dinya, A. Kovács, T. Molnár, P. Demeter, J. Papp, L. Lakatos, I. Altorjay

Research output: Article

3 Citations (Scopus)

Abstract

Background: Since functional differences were found among three major haptoglobin phenotypes, haptoglobin polymorphism was reported to be associated with the risk and clinical course of different inflammatory diseases. The aim of the study was to investigate the Hp polymorphism distribution in Hungarian Crohn's disease patients. Methods: 511 Hungarian IBD patients were investigated (Crohn's disease patients: 468, m/f ratio: 233/235, duration 8.2 ± 6.7 ys, and ulcerative colitis patients: 43, m/f: 22/21, duration: 9.5 ± 10.6 ys) and 384 healthy subjects served as controls. Hp phenotypes were determined by sodium dodecyl sulphate-polyacrylamide gel electrophoresis of sera followed by immunoblotting. Clinical data were come by the questionnaires prepared by the physicians. Result: The frequency of haptoglobin-1 allele was significantly higher in Crohn's disease (0.395) compared to the controls (0.345; OR: 1.24, 95%Cl: 1.02-1.52, p = 0.03), but the phenotype distribution showed no such differences. Haptoglobin phenotype was associated to disease behavior in Crohn's disease (B1 and B2, in haptoglobin 1-1 and 2-2: 36.6%-34.3% and 32.4%-32.5% vs. in 2-1: 44.9% and 20.3%; ORB1Hp2-1 vs. others: 2.06, 95%Cl: 1.29-3.28). Furthermore, an increased frequency of primary sclerosing cholangitis was observed in haptoglobin 2-2, compared to the 1-1 (6.5% vs. 0.0%, p = 0.039). No associations were found in ulcerative colitis. Conclusions: haptoglobin-1 allele was associated with Crohn's disease, whereas the phenotypes with the disease behavior and frequency of primary sclerosing cholangitis, exhibiting a disease-modifying effect.

Original languageHungarian
Pages (from-to)1745-1750
Number of pages6
JournalOrvosi Hetilap
Volume147
Issue number36
Publication statusPublished - szept. 10 2006

Fingerprint

Haptoglobins
Crohn Disease
Phenotype
Sclerosing Cholangitis
Ulcerative Colitis
Alleles
Immunoblotting
Sodium Dodecyl Sulfate
Polyacrylamide Gel Electrophoresis
Healthy Volunteers
Physicians
Serum

Keywords

  • Crohn's disease
  • Disease behaviour
  • Haptoglobin polymorphism
  • Primery sclerotising cholangitis
  • Th1/Th2 orientation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Haptoglobin polimorfizmus vizsgálata gyulladásos bélbetegségekben. / Papp, M.; Lakatos, P.; Fuszek, P.; Fischer, S.; Szalay, F.; Osztovics, János; Horvath, Henrik Csaba; Vargha, P.; Bene, L.; Lonovics, J.; Nagy, F.; Bálint, Levente; Huoranszky, Ferenc; Dobó, István; Tulassay, Z.; Herszényi, L.; Miheller, P.; Németh, A.; Székely, György; Erdélyi, Z.; Mester, G.; Molnár, Csaba; Pandúr, T.; Palatka, K.; Földi, Ildikó; Udvardy, M.; Hársfalvi, J.; Tornai, István; Vitális, Zuszsanna; Dinya, Tamás; Kovács, A.; Molnár, T.; Demeter, P.; Papp, J.; Lakatos, L.; Altorjay, I.

In: Orvosi Hetilap, Vol. 147, No. 36, 10.09.2006, p. 1745-1750.

Research output: Article

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title = "Haptoglobin polimorfizmus vizsg{\'a}lata gyullad{\'a}sos b{\'e}lbetegs{\'e}gekben",
abstract = "Background: Since functional differences were found among three major haptoglobin phenotypes, haptoglobin polymorphism was reported to be associated with the risk and clinical course of different inflammatory diseases. The aim of the study was to investigate the Hp polymorphism distribution in Hungarian Crohn's disease patients. Methods: 511 Hungarian IBD patients were investigated (Crohn's disease patients: 468, m/f ratio: 233/235, duration 8.2 ± 6.7 ys, and ulcerative colitis patients: 43, m/f: 22/21, duration: 9.5 ± 10.6 ys) and 384 healthy subjects served as controls. Hp phenotypes were determined by sodium dodecyl sulphate-polyacrylamide gel electrophoresis of sera followed by immunoblotting. Clinical data were come by the questionnaires prepared by the physicians. Result: The frequency of haptoglobin-1 allele was significantly higher in Crohn's disease (0.395) compared to the controls (0.345; OR: 1.24, 95{\%}Cl: 1.02-1.52, p = 0.03), but the phenotype distribution showed no such differences. Haptoglobin phenotype was associated to disease behavior in Crohn's disease (B1 and B2, in haptoglobin 1-1 and 2-2: 36.6{\%}-34.3{\%} and 32.4{\%}-32.5{\%} vs. in 2-1: 44.9{\%} and 20.3{\%}; ORB1Hp2-1 vs. others: 2.06, 95{\%}Cl: 1.29-3.28). Furthermore, an increased frequency of primary sclerosing cholangitis was observed in haptoglobin 2-2, compared to the 1-1 (6.5{\%} vs. 0.0{\%}, p = 0.039). No associations were found in ulcerative colitis. Conclusions: haptoglobin-1 allele was associated with Crohn's disease, whereas the phenotypes with the disease behavior and frequency of primary sclerosing cholangitis, exhibiting a disease-modifying effect.",
keywords = "Crohn's disease, Disease behaviour, Haptoglobin polymorphism, Primery sclerotising cholangitis, Th1/Th2 orientation",
author = "M. Papp and P. Lakatos and P. Fuszek and S. Fischer and F. Szalay and J{\'a}nos Osztovics and Horvath, {Henrik Csaba} and P. Vargha and L. Bene and J. Lonovics and F. Nagy and Levente B{\'a}lint and Ferenc Huoranszky and Istv{\'a}n Dob{\'o} and Z. Tulassay and L. Hersz{\'e}nyi and P. Miheller and A. N{\'e}meth and Gy{\"o}rgy Sz{\'e}kely and Z. Erd{\'e}lyi and G. Mester and Csaba Moln{\'a}r and T. Pand{\'u}r and K. Palatka and Ildik{\'o} F{\"o}ldi and M. Udvardy and J. H{\'a}rsfalvi and Istv{\'a}n Tornai and Zuszsanna Vit{\'a}lis and Tam{\'a}s Dinya and A. Kov{\'a}cs and T. Moln{\'a}r and P. Demeter and J. Papp and L. Lakatos and I. Altorjay",
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TY - JOUR

T1 - Haptoglobin polimorfizmus vizsgálata gyulladásos bélbetegségekben

AU - Papp, M.

AU - Lakatos, P.

AU - Fuszek, P.

AU - Fischer, S.

AU - Szalay, F.

AU - Osztovics, János

AU - Horvath, Henrik Csaba

AU - Vargha, P.

AU - Bene, L.

AU - Lonovics, J.

AU - Nagy, F.

AU - Bálint, Levente

AU - Huoranszky, Ferenc

AU - Dobó, István

AU - Tulassay, Z.

AU - Herszényi, L.

AU - Miheller, P.

AU - Németh, A.

AU - Székely, György

AU - Erdélyi, Z.

AU - Mester, G.

AU - Molnár, Csaba

AU - Pandúr, T.

AU - Palatka, K.

AU - Földi, Ildikó

AU - Udvardy, M.

AU - Hársfalvi, J.

AU - Tornai, István

AU - Vitális, Zuszsanna

AU - Dinya, Tamás

AU - Kovács, A.

AU - Molnár, T.

AU - Demeter, P.

AU - Papp, J.

AU - Lakatos, L.

AU - Altorjay, I.

PY - 2006/9/10

Y1 - 2006/9/10

N2 - Background: Since functional differences were found among three major haptoglobin phenotypes, haptoglobin polymorphism was reported to be associated with the risk and clinical course of different inflammatory diseases. The aim of the study was to investigate the Hp polymorphism distribution in Hungarian Crohn's disease patients. Methods: 511 Hungarian IBD patients were investigated (Crohn's disease patients: 468, m/f ratio: 233/235, duration 8.2 ± 6.7 ys, and ulcerative colitis patients: 43, m/f: 22/21, duration: 9.5 ± 10.6 ys) and 384 healthy subjects served as controls. Hp phenotypes were determined by sodium dodecyl sulphate-polyacrylamide gel electrophoresis of sera followed by immunoblotting. Clinical data were come by the questionnaires prepared by the physicians. Result: The frequency of haptoglobin-1 allele was significantly higher in Crohn's disease (0.395) compared to the controls (0.345; OR: 1.24, 95%Cl: 1.02-1.52, p = 0.03), but the phenotype distribution showed no such differences. Haptoglobin phenotype was associated to disease behavior in Crohn's disease (B1 and B2, in haptoglobin 1-1 and 2-2: 36.6%-34.3% and 32.4%-32.5% vs. in 2-1: 44.9% and 20.3%; ORB1Hp2-1 vs. others: 2.06, 95%Cl: 1.29-3.28). Furthermore, an increased frequency of primary sclerosing cholangitis was observed in haptoglobin 2-2, compared to the 1-1 (6.5% vs. 0.0%, p = 0.039). No associations were found in ulcerative colitis. Conclusions: haptoglobin-1 allele was associated with Crohn's disease, whereas the phenotypes with the disease behavior and frequency of primary sclerosing cholangitis, exhibiting a disease-modifying effect.

AB - Background: Since functional differences were found among three major haptoglobin phenotypes, haptoglobin polymorphism was reported to be associated with the risk and clinical course of different inflammatory diseases. The aim of the study was to investigate the Hp polymorphism distribution in Hungarian Crohn's disease patients. Methods: 511 Hungarian IBD patients were investigated (Crohn's disease patients: 468, m/f ratio: 233/235, duration 8.2 ± 6.7 ys, and ulcerative colitis patients: 43, m/f: 22/21, duration: 9.5 ± 10.6 ys) and 384 healthy subjects served as controls. Hp phenotypes were determined by sodium dodecyl sulphate-polyacrylamide gel electrophoresis of sera followed by immunoblotting. Clinical data were come by the questionnaires prepared by the physicians. Result: The frequency of haptoglobin-1 allele was significantly higher in Crohn's disease (0.395) compared to the controls (0.345; OR: 1.24, 95%Cl: 1.02-1.52, p = 0.03), but the phenotype distribution showed no such differences. Haptoglobin phenotype was associated to disease behavior in Crohn's disease (B1 and B2, in haptoglobin 1-1 and 2-2: 36.6%-34.3% and 32.4%-32.5% vs. in 2-1: 44.9% and 20.3%; ORB1Hp2-1 vs. others: 2.06, 95%Cl: 1.29-3.28). Furthermore, an increased frequency of primary sclerosing cholangitis was observed in haptoglobin 2-2, compared to the 1-1 (6.5% vs. 0.0%, p = 0.039). No associations were found in ulcerative colitis. Conclusions: haptoglobin-1 allele was associated with Crohn's disease, whereas the phenotypes with the disease behavior and frequency of primary sclerosing cholangitis, exhibiting a disease-modifying effect.

KW - Crohn's disease

KW - Disease behaviour

KW - Haptoglobin polymorphism

KW - Primery sclerotising cholangitis

KW - Th1/Th2 orientation

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