Haematopoietic stem cell transplantation in children in eastern European countries 1985-2004: Development, recent activity and role of the EBMT/ ESH Outreach Programme

J. Wachowiak, M. Labopin, M. Miano, A. Chybicka, J. Stary, J. Sterba, T. Masszi, B. Labar, A. Maschan, J. R. Kowalczyk, A. Lange, J. Holowiecki, K. Nagy, B. V. Afanassiev, G. Dini

Research output: Article

14 Citations (Scopus)

Abstract

The paediatric population of 19 eastern European countries amounts to approximately 80 million children. Between 1985 and 2004, the number of centres performing haematopoietic stem cell transplantation (HSCT) in children increased from 1 in 1985 to 24 in 2004 and the yearly number of paediatric HSCTs rose from 1 in 1985 to 291 in 2004. Altogether, 2342 transplants were reported to the EBMT Registry during this time (Poland 953, Czech Republic 501, Hungary 269, Russia 217, Croatia 129, Slovakia 71, Bulgaria 45, Serbia and Montenegro 36, Slovenia 35, Belarus 33, Estonia 26, Lithuania 19 and Romania 8). Out of the 2342 transplants, 1487 (63.5%) transplants were performed in paediatric centres, 453 (19.3%) in centres for adults and 402 (17.2%) in combined centres. The number of children who underwent autologous HSCT (auto-HSCT) was 1053 (45%), whereas 1289 (55%) underwent allogeneic HSCT (allo-HSCT). Peripheral blood (PB) was the source of HSC in 751 (71.3%) out of 1053 auto-transplants, BM in 246 (23.4%) and PB+BM in 52 (4.9%) (missing data in 4, that is, 0.4%). Among the 1289 allo-transplants, BM was the source of HSC in 827 (64.3%), PB in 416 (32.3%), CB in 23 (1.8%) and BM+PB in 14 (1.1%) (missing data in 9, that is, 0.7%). Among them, 728 (57.4%) obtained HSC from MSD, 322 (25.4%) from UD, 195 (15.4%) from MMFD, 14 (1.1%) from CB family donor and 9 (0.7%) from CB unrelated donor (missing data in 21, that is, 1.6%). The number of children who underwent allo-HSCT for malignant diseases was 945 (73.4%), including ALL 376 (29.2%), AML 234 (18.2%), CML 177 (13.8%), MDS 97 (7.5%), NHL 35 (2.7%) and other malignancy 31 (2.4%), while 339 (26.9%) for non-malignant disorders, including SAA 202 (15.7%), immunodeficiencies 61 (4.7%), inborn errors of metabolism 40 (3.1%), Fanconi anaemia 19 (1.5%) and others 17 (1.3%). Out of 1053 recipients of auto-HSCT, 168 (16%) were transplanted for neuroblastoma, 129 (12.2%) for NHL, 124 (11.7%) for AML, 114 (10.8%) for ALL, 109 (10.4%) for Hodgkin's disease, 62 (5.9%) for Ewing's sarcoma, 16 (1.5%) for CNS tumour, 15 (1.4%) for Wilms tumour and 316 (30%) for other tumours. In 2001, the EBMT in collaboration with the European School of Haematology (ESH) developed the Outreach Programme, that is a programme supporting emerging HSCT projects and transplant centres in countries with limited resources and/or experience.

Original languageEnglish
JournalBone Marrow Transplantation
Volume41
Issue numberSUPPL. 2
DOIs
Publication statusPublished - jún. 2008

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Hematopoietic Stem Cell Transplantation
Hematology
Transplants
Pediatrics
Montenegro
Republic of Belarus
Estonia
Lithuania
Slovenia
Serbia
Fanconi Anemia
Inborn Errors Metabolism
Bulgaria
Romania
Slovakia
Neoplasms
Unrelated Donors
Croatia
Ewing's Sarcoma
Wilms Tumor

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Haematopoietic stem cell transplantation in children in eastern European countries 1985-2004 : Development, recent activity and role of the EBMT/ ESH Outreach Programme. / Wachowiak, J.; Labopin, M.; Miano, M.; Chybicka, A.; Stary, J.; Sterba, J.; Masszi, T.; Labar, B.; Maschan, A.; Kowalczyk, J. R.; Lange, A.; Holowiecki, J.; Nagy, K.; Afanassiev, B. V.; Dini, G.

In: Bone Marrow Transplantation, Vol. 41, No. SUPPL. 2, 06.2008.

Research output: Article

Wachowiak, J, Labopin, M, Miano, M, Chybicka, A, Stary, J, Sterba, J, Masszi, T, Labar, B, Maschan, A, Kowalczyk, JR, Lange, A, Holowiecki, J, Nagy, K, Afanassiev, BV & Dini, G 2008, 'Haematopoietic stem cell transplantation in children in eastern European countries 1985-2004: Development, recent activity and role of the EBMT/ ESH Outreach Programme', Bone Marrow Transplantation, vol. 41, no. SUPPL. 2. https://doi.org/10.1038/bmt.2008.68
Wachowiak, J. ; Labopin, M. ; Miano, M. ; Chybicka, A. ; Stary, J. ; Sterba, J. ; Masszi, T. ; Labar, B. ; Maschan, A. ; Kowalczyk, J. R. ; Lange, A. ; Holowiecki, J. ; Nagy, K. ; Afanassiev, B. V. ; Dini, G. / Haematopoietic stem cell transplantation in children in eastern European countries 1985-2004 : Development, recent activity and role of the EBMT/ ESH Outreach Programme. In: Bone Marrow Transplantation. 2008 ; Vol. 41, No. SUPPL. 2.
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abstract = "The paediatric population of 19 eastern European countries amounts to approximately 80 million children. Between 1985 and 2004, the number of centres performing haematopoietic stem cell transplantation (HSCT) in children increased from 1 in 1985 to 24 in 2004 and the yearly number of paediatric HSCTs rose from 1 in 1985 to 291 in 2004. Altogether, 2342 transplants were reported to the EBMT Registry during this time (Poland 953, Czech Republic 501, Hungary 269, Russia 217, Croatia 129, Slovakia 71, Bulgaria 45, Serbia and Montenegro 36, Slovenia 35, Belarus 33, Estonia 26, Lithuania 19 and Romania 8). Out of the 2342 transplants, 1487 (63.5{\%}) transplants were performed in paediatric centres, 453 (19.3{\%}) in centres for adults and 402 (17.2{\%}) in combined centres. The number of children who underwent autologous HSCT (auto-HSCT) was 1053 (45{\%}), whereas 1289 (55{\%}) underwent allogeneic HSCT (allo-HSCT). Peripheral blood (PB) was the source of HSC in 751 (71.3{\%}) out of 1053 auto-transplants, BM in 246 (23.4{\%}) and PB+BM in 52 (4.9{\%}) (missing data in 4, that is, 0.4{\%}). Among the 1289 allo-transplants, BM was the source of HSC in 827 (64.3{\%}), PB in 416 (32.3{\%}), CB in 23 (1.8{\%}) and BM+PB in 14 (1.1{\%}) (missing data in 9, that is, 0.7{\%}). Among them, 728 (57.4{\%}) obtained HSC from MSD, 322 (25.4{\%}) from UD, 195 (15.4{\%}) from MMFD, 14 (1.1{\%}) from CB family donor and 9 (0.7{\%}) from CB unrelated donor (missing data in 21, that is, 1.6{\%}). The number of children who underwent allo-HSCT for malignant diseases was 945 (73.4{\%}), including ALL 376 (29.2{\%}), AML 234 (18.2{\%}), CML 177 (13.8{\%}), MDS 97 (7.5{\%}), NHL 35 (2.7{\%}) and other malignancy 31 (2.4{\%}), while 339 (26.9{\%}) for non-malignant disorders, including SAA 202 (15.7{\%}), immunodeficiencies 61 (4.7{\%}), inborn errors of metabolism 40 (3.1{\%}), Fanconi anaemia 19 (1.5{\%}) and others 17 (1.3{\%}). Out of 1053 recipients of auto-HSCT, 168 (16{\%}) were transplanted for neuroblastoma, 129 (12.2{\%}) for NHL, 124 (11.7{\%}) for AML, 114 (10.8{\%}) for ALL, 109 (10.4{\%}) for Hodgkin's disease, 62 (5.9{\%}) for Ewing's sarcoma, 16 (1.5{\%}) for CNS tumour, 15 (1.4{\%}) for Wilms tumour and 316 (30{\%}) for other tumours. In 2001, the EBMT in collaboration with the European School of Haematology (ESH) developed the Outreach Programme, that is a programme supporting emerging HSCT projects and transplant centres in countries with limited resources and/or experience.",
author = "J. Wachowiak and M. Labopin and M. Miano and A. Chybicka and J. Stary and J. Sterba and T. Masszi and B. Labar and A. Maschan and Kowalczyk, {J. R.} and A. Lange and J. Holowiecki and K. Nagy and Afanassiev, {B. V.} and G. Dini",
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T1 - Haematopoietic stem cell transplantation in children in eastern European countries 1985-2004

T2 - Development, recent activity and role of the EBMT/ ESH Outreach Programme

AU - Wachowiak, J.

AU - Labopin, M.

AU - Miano, M.

AU - Chybicka, A.

AU - Stary, J.

AU - Sterba, J.

AU - Masszi, T.

AU - Labar, B.

AU - Maschan, A.

AU - Kowalczyk, J. R.

AU - Lange, A.

AU - Holowiecki, J.

AU - Nagy, K.

AU - Afanassiev, B. V.

AU - Dini, G.

PY - 2008/6

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N2 - The paediatric population of 19 eastern European countries amounts to approximately 80 million children. Between 1985 and 2004, the number of centres performing haematopoietic stem cell transplantation (HSCT) in children increased from 1 in 1985 to 24 in 2004 and the yearly number of paediatric HSCTs rose from 1 in 1985 to 291 in 2004. Altogether, 2342 transplants were reported to the EBMT Registry during this time (Poland 953, Czech Republic 501, Hungary 269, Russia 217, Croatia 129, Slovakia 71, Bulgaria 45, Serbia and Montenegro 36, Slovenia 35, Belarus 33, Estonia 26, Lithuania 19 and Romania 8). Out of the 2342 transplants, 1487 (63.5%) transplants were performed in paediatric centres, 453 (19.3%) in centres for adults and 402 (17.2%) in combined centres. The number of children who underwent autologous HSCT (auto-HSCT) was 1053 (45%), whereas 1289 (55%) underwent allogeneic HSCT (allo-HSCT). Peripheral blood (PB) was the source of HSC in 751 (71.3%) out of 1053 auto-transplants, BM in 246 (23.4%) and PB+BM in 52 (4.9%) (missing data in 4, that is, 0.4%). Among the 1289 allo-transplants, BM was the source of HSC in 827 (64.3%), PB in 416 (32.3%), CB in 23 (1.8%) and BM+PB in 14 (1.1%) (missing data in 9, that is, 0.7%). Among them, 728 (57.4%) obtained HSC from MSD, 322 (25.4%) from UD, 195 (15.4%) from MMFD, 14 (1.1%) from CB family donor and 9 (0.7%) from CB unrelated donor (missing data in 21, that is, 1.6%). The number of children who underwent allo-HSCT for malignant diseases was 945 (73.4%), including ALL 376 (29.2%), AML 234 (18.2%), CML 177 (13.8%), MDS 97 (7.5%), NHL 35 (2.7%) and other malignancy 31 (2.4%), while 339 (26.9%) for non-malignant disorders, including SAA 202 (15.7%), immunodeficiencies 61 (4.7%), inborn errors of metabolism 40 (3.1%), Fanconi anaemia 19 (1.5%) and others 17 (1.3%). Out of 1053 recipients of auto-HSCT, 168 (16%) were transplanted for neuroblastoma, 129 (12.2%) for NHL, 124 (11.7%) for AML, 114 (10.8%) for ALL, 109 (10.4%) for Hodgkin's disease, 62 (5.9%) for Ewing's sarcoma, 16 (1.5%) for CNS tumour, 15 (1.4%) for Wilms tumour and 316 (30%) for other tumours. In 2001, the EBMT in collaboration with the European School of Haematology (ESH) developed the Outreach Programme, that is a programme supporting emerging HSCT projects and transplant centres in countries with limited resources and/or experience.

AB - The paediatric population of 19 eastern European countries amounts to approximately 80 million children. Between 1985 and 2004, the number of centres performing haematopoietic stem cell transplantation (HSCT) in children increased from 1 in 1985 to 24 in 2004 and the yearly number of paediatric HSCTs rose from 1 in 1985 to 291 in 2004. Altogether, 2342 transplants were reported to the EBMT Registry during this time (Poland 953, Czech Republic 501, Hungary 269, Russia 217, Croatia 129, Slovakia 71, Bulgaria 45, Serbia and Montenegro 36, Slovenia 35, Belarus 33, Estonia 26, Lithuania 19 and Romania 8). Out of the 2342 transplants, 1487 (63.5%) transplants were performed in paediatric centres, 453 (19.3%) in centres for adults and 402 (17.2%) in combined centres. The number of children who underwent autologous HSCT (auto-HSCT) was 1053 (45%), whereas 1289 (55%) underwent allogeneic HSCT (allo-HSCT). Peripheral blood (PB) was the source of HSC in 751 (71.3%) out of 1053 auto-transplants, BM in 246 (23.4%) and PB+BM in 52 (4.9%) (missing data in 4, that is, 0.4%). Among the 1289 allo-transplants, BM was the source of HSC in 827 (64.3%), PB in 416 (32.3%), CB in 23 (1.8%) and BM+PB in 14 (1.1%) (missing data in 9, that is, 0.7%). Among them, 728 (57.4%) obtained HSC from MSD, 322 (25.4%) from UD, 195 (15.4%) from MMFD, 14 (1.1%) from CB family donor and 9 (0.7%) from CB unrelated donor (missing data in 21, that is, 1.6%). The number of children who underwent allo-HSCT for malignant diseases was 945 (73.4%), including ALL 376 (29.2%), AML 234 (18.2%), CML 177 (13.8%), MDS 97 (7.5%), NHL 35 (2.7%) and other malignancy 31 (2.4%), while 339 (26.9%) for non-malignant disorders, including SAA 202 (15.7%), immunodeficiencies 61 (4.7%), inborn errors of metabolism 40 (3.1%), Fanconi anaemia 19 (1.5%) and others 17 (1.3%). Out of 1053 recipients of auto-HSCT, 168 (16%) were transplanted for neuroblastoma, 129 (12.2%) for NHL, 124 (11.7%) for AML, 114 (10.8%) for ALL, 109 (10.4%) for Hodgkin's disease, 62 (5.9%) for Ewing's sarcoma, 16 (1.5%) for CNS tumour, 15 (1.4%) for Wilms tumour and 316 (30%) for other tumours. In 2001, the EBMT in collaboration with the European School of Haematology (ESH) developed the Outreach Programme, that is a programme supporting emerging HSCT projects and transplant centres in countries with limited resources and/or experience.

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