We have recently demonstrated that genes within the major histocompatibility complex (MHC) are relevant to Graves' eye liability against the background of DR3 influence on susceptibility to Graves' hyperthyroidism. Interactions between specific class I and class II alleles were found to predispose to (B8/DR7) as well as protect against (B35/DR4) eye disease [Frecker et al., 1986, in press]. In the Hungarian series of patients in whom the linkage disequilibrium between B8 and DR3 is not as strong as in Newfoundlanders, HLA-B8 appeared to be more strongly associated with eye disease than was DR3 [Frecker et al., 1986]. There is as yet no study relating HLA alleles to cell-mediated or humoral immunity to retro-orbital-tissue antigens which was demonstrated in Graves' eye disease [Wall, 1984]. The present study explores this relation.
|Number of pages||3|
|Journal||Experimental and Clinical Immunogenetics|
|Publication status||Published - jan. 1 1989|
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