Gram-negatív bacteriaemia neutropeniás hematológiai betegekben. Tapasztalatok fluorokinolonprofilaxis alkalmazása kapcsán

János Sinkó, Viktória Cser, Marianne Konkoly Thege, T. Masszi

Research output: Article

3 Citations (Scopus)

Abstract

Gram-negative bacteremia remains a severe complication of neutropenia with a high mortality rate. For high-risk patients prophylactic use of fluoroquinolones is recommended as a preventive strategy. Aims: To study the effect of fluoroquinolone prophylaxis on Gram-negative bacteremia. Methods: In the retrospective survey Gram-negative bacteremic episodes occurring in a centre for hematology and stem cell transplantation were studied. Data from the year before and after instituting prophylaxis were compared with regard to the incidence of blood stream infections, spectrum of pathogens, rate of fluoroquinolone resistance and all cause mortality of affected patient population. Results: Only a slight decrease in the incidence of Gram-negative bacteremia was seen (ARR: 0.024) after the introduction of fluoroquinolone prophylaxis. Spectrum of pathogens remained unchanged. However, the proportion of fluoroquinolone resistant Gram-negative isolates increased markedly (from 24% to 59%, p = 0.001), especially fluoroquinolone resistant E. coli strains became more prevalent (from 16% to 75%, p

Original languageHungarian
Pages (from-to)1063-1067
Number of pages5
JournalOrvosi Hetilap
Volume152
Issue number27
DOIs
Publication statusPublished - júl. 1 2011

Fingerprint

Fluoroquinolones
Bacteremia
Mortality
Incidence
Stem Cell Transplantation
Hematology
Neutropenia
Escherichia coli
Infection
Population

Keywords

  • fluoroquinolone prophylaxis
  • fluoroquinolone resistance
  • Gram-negative bacteremia
  • neutropenia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gram-negatív bacteriaemia neutropeniás hematológiai betegekben. Tapasztalatok fluorokinolonprofilaxis alkalmazása kapcsán. / Sinkó, János; Cser, Viktória; Konkoly Thege, Marianne; Masszi, T.

In: Orvosi Hetilap, Vol. 152, No. 27, 01.07.2011, p. 1063-1067.

Research output: Article

Sinkó, János ; Cser, Viktória ; Konkoly Thege, Marianne ; Masszi, T. / Gram-negatív bacteriaemia neutropeniás hematológiai betegekben. Tapasztalatok fluorokinolonprofilaxis alkalmazása kapcsán. In: Orvosi Hetilap. 2011 ; Vol. 152, No. 27. pp. 1063-1067.
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