GFP transgenic animals in biomedical research: A review of potential disadvantages

N. Lipták, Z. Bösze, L. Hiripi

Research output: Review article

Abstract

Green Fluorescent protein (GFP) transgenic animals are accepted tools for studying various physiological processes, including organ development and cell migration. However, several in vivo studies claimed that GFP may impair transgenic animals' health. Glomerulosclerosis was observed in transgenic mice and rabbits with ubiquitous reporter protein expression. Heart-specific GFP expression evoked dilated cardiomyopathy and altered cardiac function in transgenic mouse and zebrafish lines, respectively. Moreover, growth retardation and increased axon swelling were observed in GFP and yellow fluorescent protein (YFP) transgenic mice, respectively. This review will focus on the potential drawbacks of the applications of GFP transgenic animals in biomedical research.

Original languageEnglish
Pages (from-to)525-530
Number of pages6
JournalPhysiological Research
Volume68
Issue number4
DOIs
Publication statusPublished - jan. 1 2019

Fingerprint

Genetically Modified Animals
Green Fluorescent Proteins
Biomedical Research
Transgenic Mice
Physiological Phenomena
Dilated Cardiomyopathy
Zebrafish
Cell Movement
Axons
Proteins
Rabbits
Health
Growth

ASJC Scopus subject areas

  • Physiology

Cite this

GFP transgenic animals in biomedical research : A review of potential disadvantages. / Lipták, N.; Bösze, Z.; Hiripi, L.

In: Physiological Research, Vol. 68, No. 4, 01.01.2019, p. 525-530.

Research output: Review article

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