Asthma is a pulmonary disease characterized by increased bronchial responsiveness to a variety of stimuli. It is the most common chronic disease of childhood and the most frequent reason for paediatric hospital admission, and its incidence is on the rise. Several studies have suggested that asthma is a multifactorial disease influenced by genetic and environmental factors. In this review I will systematically summarize collective evidence from linkage and association studies that have consistently reported suggestive linkage or association of asthma or its associated phenotypes to polymorphic markers and single nucleotide polymorphisms in selected chromosomes. Next, I will show some results from animal models of asthma investigating the pathomechanism and the genomic background of the disease.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)