Abstract
As stroke is the third leading cause of death after heart failure and tumors worldwide, cerebrovascular diseases reached substantial attention. In the past few years, significant progression has been seen in identification of genetic variants in the background of stroke and other cerebrovascular and cardiovascular events. Examination of these variants is a new approach to recognize pathogenesis of disorders that hopefully helps in future prevention and prospects of screening and, optimistically, it contributes to special care of patients susceptible for stroke. In the background of ischemic stroke several genetic variants have been identified, which localize in genes encoding proteins involved in hemostasis, renin-angiotensin system and lipid metabolism. The number of these variants exponentially increases permanently due to rapid spreading of genome wide association studies. The goal of this review is to summarize the results of genetic studies on ischemic stroke. Here the authors focus on genetic variants which can have major role in personalized medicine and prevention of stroke.
| Original language | Hungarian |
|---|---|
| Pages (from-to) | 455-463 |
| Number of pages | 9 |
| Journal | Orvosi Hetilap |
| Volume | 152 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - márc. 1 2011 |
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Keywords
- genetics
- genetika
- GWAS
- ischaemiás stroke
- ischemic stroke
- stroke
ASJC Scopus subject areas
- Medicine(all)
Cite this
Ischaemiás stroke genetikai háttere : Hol tartunk most? / Maász, A.; Szolnoki, Z.; Balikó, L.; Melegh, B.
In: Orvosi Hetilap, Vol. 152, No. 12, 01.03.2011, p. 455-463.Research output: Article
}
TY - JOUR
T1 - Ischaemiás stroke genetikai háttere
T2 - Hol tartunk most?
AU - Maász, A.
AU - Szolnoki, Z.
AU - Balikó, L.
AU - Melegh, B.
PY - 2011/3/1
Y1 - 2011/3/1
N2 - As stroke is the third leading cause of death after heart failure and tumors worldwide, cerebrovascular diseases reached substantial attention. In the past few years, significant progression has been seen in identification of genetic variants in the background of stroke and other cerebrovascular and cardiovascular events. Examination of these variants is a new approach to recognize pathogenesis of disorders that hopefully helps in future prevention and prospects of screening and, optimistically, it contributes to special care of patients susceptible for stroke. In the background of ischemic stroke several genetic variants have been identified, which localize in genes encoding proteins involved in hemostasis, renin-angiotensin system and lipid metabolism. The number of these variants exponentially increases permanently due to rapid spreading of genome wide association studies. The goal of this review is to summarize the results of genetic studies on ischemic stroke. Here the authors focus on genetic variants which can have major role in personalized medicine and prevention of stroke.
AB - As stroke is the third leading cause of death after heart failure and tumors worldwide, cerebrovascular diseases reached substantial attention. In the past few years, significant progression has been seen in identification of genetic variants in the background of stroke and other cerebrovascular and cardiovascular events. Examination of these variants is a new approach to recognize pathogenesis of disorders that hopefully helps in future prevention and prospects of screening and, optimistically, it contributes to special care of patients susceptible for stroke. In the background of ischemic stroke several genetic variants have been identified, which localize in genes encoding proteins involved in hemostasis, renin-angiotensin system and lipid metabolism. The number of these variants exponentially increases permanently due to rapid spreading of genome wide association studies. The goal of this review is to summarize the results of genetic studies on ischemic stroke. Here the authors focus on genetic variants which can have major role in personalized medicine and prevention of stroke.
KW - genetics
KW - genetika
KW - GWAS
KW - ischaemiás stroke
KW - ischemic stroke
KW - stroke
UR - http://www.scopus.com/inward/record.url?scp=79952600025&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79952600025&partnerID=8YFLogxK
U2 - 10.1556/OH.2011.29069
DO - 10.1556/OH.2011.29069
M3 - Article
C2 - 21388942
AN - SCOPUS:79952600025
VL - 152
SP - 455
EP - 463
JO - Orvosi Hetilap
JF - Orvosi Hetilap
SN - 0030-6002
IS - 12
ER -