Ischaemiás stroke genetikai háttere: Hol tartunk most?

Research output: Article

1 Citation (Scopus)

Abstract

As stroke is the third leading cause of death after heart failure and tumors worldwide, cerebrovascular diseases reached substantial attention. In the past few years, significant progression has been seen in identification of genetic variants in the background of stroke and other cerebrovascular and cardiovascular events. Examination of these variants is a new approach to recognize pathogenesis of disorders that hopefully helps in future prevention and prospects of screening and, optimistically, it contributes to special care of patients susceptible for stroke. In the background of ischemic stroke several genetic variants have been identified, which localize in genes encoding proteins involved in hemostasis, renin-angiotensin system and lipid metabolism. The number of these variants exponentially increases permanently due to rapid spreading of genome wide association studies. The goal of this review is to summarize the results of genetic studies on ischemic stroke. Here the authors focus on genetic variants which can have major role in personalized medicine and prevention of stroke.

Original languageHungarian
Pages (from-to)455-463
Number of pages9
JournalOrvosi Hetilap
Volume152
Issue number12
DOIs
Publication statusPublished - márc. 1 2011

Fingerprint

Stroke
Cerebrovascular Disorders
Precision Medicine
Heart Neoplasms
Genome-Wide Association Study
Renin-Angiotensin System
Hemostasis
Lipid Metabolism
Cause of Death
Patient Care
Heart Failure
Myocardial Infarction
Proteins

Keywords

  • genetics
  • genetika
  • GWAS
  • ischaemiás stroke
  • ischemic stroke
  • stroke

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{fd8e398afb5945119d4894144f49f0e3,
title = "Ischaemi{\'a}s stroke genetikai h{\'a}ttere: Hol tartunk most?",
abstract = "As stroke is the third leading cause of death after heart failure and tumors worldwide, cerebrovascular diseases reached substantial attention. In the past few years, significant progression has been seen in identification of genetic variants in the background of stroke and other cerebrovascular and cardiovascular events. Examination of these variants is a new approach to recognize pathogenesis of disorders that hopefully helps in future prevention and prospects of screening and, optimistically, it contributes to special care of patients susceptible for stroke. In the background of ischemic stroke several genetic variants have been identified, which localize in genes encoding proteins involved in hemostasis, renin-angiotensin system and lipid metabolism. The number of these variants exponentially increases permanently due to rapid spreading of genome wide association studies. The goal of this review is to summarize the results of genetic studies on ischemic stroke. Here the authors focus on genetic variants which can have major role in personalized medicine and prevention of stroke.",
keywords = "genetics, genetika, GWAS, ischaemi{\'a}s stroke, ischemic stroke, stroke",
author = "A. Ma{\'a}sz and Z. Szolnoki and L. Balik{\'o} and B. Melegh",
year = "2011",
month = "3",
day = "1",
doi = "10.1556/OH.2011.29069",
language = "Hungarian",
volume = "152",
pages = "455--463",
journal = "Orvosi Hetilap",
issn = "0030-6002",
publisher = "Akademiai Kiado",
number = "12",

}

TY - JOUR

T1 - Ischaemiás stroke genetikai háttere

T2 - Hol tartunk most?

AU - Maász, A.

AU - Szolnoki, Z.

AU - Balikó, L.

AU - Melegh, B.

PY - 2011/3/1

Y1 - 2011/3/1

N2 - As stroke is the third leading cause of death after heart failure and tumors worldwide, cerebrovascular diseases reached substantial attention. In the past few years, significant progression has been seen in identification of genetic variants in the background of stroke and other cerebrovascular and cardiovascular events. Examination of these variants is a new approach to recognize pathogenesis of disorders that hopefully helps in future prevention and prospects of screening and, optimistically, it contributes to special care of patients susceptible for stroke. In the background of ischemic stroke several genetic variants have been identified, which localize in genes encoding proteins involved in hemostasis, renin-angiotensin system and lipid metabolism. The number of these variants exponentially increases permanently due to rapid spreading of genome wide association studies. The goal of this review is to summarize the results of genetic studies on ischemic stroke. Here the authors focus on genetic variants which can have major role in personalized medicine and prevention of stroke.

AB - As stroke is the third leading cause of death after heart failure and tumors worldwide, cerebrovascular diseases reached substantial attention. In the past few years, significant progression has been seen in identification of genetic variants in the background of stroke and other cerebrovascular and cardiovascular events. Examination of these variants is a new approach to recognize pathogenesis of disorders that hopefully helps in future prevention and prospects of screening and, optimistically, it contributes to special care of patients susceptible for stroke. In the background of ischemic stroke several genetic variants have been identified, which localize in genes encoding proteins involved in hemostasis, renin-angiotensin system and lipid metabolism. The number of these variants exponentially increases permanently due to rapid spreading of genome wide association studies. The goal of this review is to summarize the results of genetic studies on ischemic stroke. Here the authors focus on genetic variants which can have major role in personalized medicine and prevention of stroke.

KW - genetics

KW - genetika

KW - GWAS

KW - ischaemiás stroke

KW - ischemic stroke

KW - stroke

UR - http://www.scopus.com/inward/record.url?scp=79952600025&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952600025&partnerID=8YFLogxK

U2 - 10.1556/OH.2011.29069

DO - 10.1556/OH.2011.29069

M3 - Article

C2 - 21388942

AN - SCOPUS:79952600025

VL - 152

SP - 455

EP - 463

JO - Orvosi Hetilap

JF - Orvosi Hetilap

SN - 0030-6002

IS - 12

ER -