Genetic variability and haplotype profile of MDR1 (ABCB1) in roma and Hungarian population samples with a review of the literature

C. Sipeky, V. Csöngei, L. Járomi, E. Sáfrány, A. Maász, Istvan Takacs, Judit Beres, L. Fodor, Melinda Szabo, B. Melegh

Research output: Article

29 Citations (Scopus)

Abstract

The genetic variability, haplotype profile and ethnic differences of MDR1 polymorphisms in healthy Roma and Hungarian populations were analyzed and the results were compared with those of other populations available from the literature. Healthy subjects (465 Roma and 503 Hungarian) were genotyped for C1236T, G2677T/A and C3435T variants of MDR1 by PCR-RFLP assay. Differences were found between the Roma and Hungarian populations in the frequencies of MDR1 1236 CC (20.7 vs. 33.2%) and TT genotypes (30.8 vs. 21.9%), in T allele frequency (0.551 vs. 0.443) (p <0.002), and in 3435T allele frequency (0.482 vs. 0.527, p <0.04). Furthermore, the frequency of CGC, CGT and CTT haplotypes was significantly higher in the Hungarian population than in Roma (41.4 vs. 35.3%, 9.04 vs. 6.02% and 2.88 vs. 1.08%, respectively; p <0.009), whereas the frequency of TGC and TTC haplotypes was higher in the Roma population than in the Hungarian (7.31 vs. 1.68% and 6.67 vs. 2.08%, respectively; p <0.001). The prevalence of MDR1 polymorphisms in the Hungarian population is similar to that of other European populations; however, some differences were observed in the haplotype structures. In contrast, the Roma population differs from Hungarians, from Caucasians and from populations from India in the incidence of MDR1 common variants and haplotypes.

Original languageEnglish
Pages (from-to)206-215
Number of pages10
JournalDrug Metabolism and Pharmacokinetics
Volume26
Issue number2
DOIs
Publication statusPublished - 2011

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Roma
Haplotypes
Population
Gene Frequency
Restriction Fragment Length Polymorphisms
India
Healthy Volunteers
Genotype
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Pharmaceutical Science

Cite this

@article{dad9cfd5bdc8491a9b367e7e839cb4bb,
title = "Genetic variability and haplotype profile of MDR1 (ABCB1) in roma and Hungarian population samples with a review of the literature",
abstract = "The genetic variability, haplotype profile and ethnic differences of MDR1 polymorphisms in healthy Roma and Hungarian populations were analyzed and the results were compared with those of other populations available from the literature. Healthy subjects (465 Roma and 503 Hungarian) were genotyped for C1236T, G2677T/A and C3435T variants of MDR1 by PCR-RFLP assay. Differences were found between the Roma and Hungarian populations in the frequencies of MDR1 1236 CC (20.7 vs. 33.2{\%}) and TT genotypes (30.8 vs. 21.9{\%}), in T allele frequency (0.551 vs. 0.443) (p <0.002), and in 3435T allele frequency (0.482 vs. 0.527, p <0.04). Furthermore, the frequency of CGC, CGT and CTT haplotypes was significantly higher in the Hungarian population than in Roma (41.4 vs. 35.3{\%}, 9.04 vs. 6.02{\%} and 2.88 vs. 1.08{\%}, respectively; p <0.009), whereas the frequency of TGC and TTC haplotypes was higher in the Roma population than in the Hungarian (7.31 vs. 1.68{\%} and 6.67 vs. 2.08{\%}, respectively; p <0.001). The prevalence of MDR1 polymorphisms in the Hungarian population is similar to that of other European populations; however, some differences were observed in the haplotype structures. In contrast, the Roma population differs from Hungarians, from Caucasians and from populations from India in the incidence of MDR1 common variants and haplotypes.",
keywords = "C1236T, C3435T, G2677T/A, Haplotype profile, Hungarian, Interethnic differences, MDR1 (ABCB1), Roma",
author = "C. Sipeky and V. Cs{\"o}ngei and L. J{\'a}romi and E. S{\'a}fr{\'a}ny and A. Ma{\'a}sz and Istvan Takacs and Judit Beres and L. Fodor and Melinda Szabo and B. Melegh",
year = "2011",
doi = "10.2133/dmpk.DMPK-10-SC-068",
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volume = "26",
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TY - JOUR

T1 - Genetic variability and haplotype profile of MDR1 (ABCB1) in roma and Hungarian population samples with a review of the literature

AU - Sipeky, C.

AU - Csöngei, V.

AU - Járomi, L.

AU - Sáfrány, E.

AU - Maász, A.

AU - Takacs, Istvan

AU - Beres, Judit

AU - Fodor, L.

AU - Szabo, Melinda

AU - Melegh, B.

PY - 2011

Y1 - 2011

N2 - The genetic variability, haplotype profile and ethnic differences of MDR1 polymorphisms in healthy Roma and Hungarian populations were analyzed and the results were compared with those of other populations available from the literature. Healthy subjects (465 Roma and 503 Hungarian) were genotyped for C1236T, G2677T/A and C3435T variants of MDR1 by PCR-RFLP assay. Differences were found between the Roma and Hungarian populations in the frequencies of MDR1 1236 CC (20.7 vs. 33.2%) and TT genotypes (30.8 vs. 21.9%), in T allele frequency (0.551 vs. 0.443) (p <0.002), and in 3435T allele frequency (0.482 vs. 0.527, p <0.04). Furthermore, the frequency of CGC, CGT and CTT haplotypes was significantly higher in the Hungarian population than in Roma (41.4 vs. 35.3%, 9.04 vs. 6.02% and 2.88 vs. 1.08%, respectively; p <0.009), whereas the frequency of TGC and TTC haplotypes was higher in the Roma population than in the Hungarian (7.31 vs. 1.68% and 6.67 vs. 2.08%, respectively; p <0.001). The prevalence of MDR1 polymorphisms in the Hungarian population is similar to that of other European populations; however, some differences were observed in the haplotype structures. In contrast, the Roma population differs from Hungarians, from Caucasians and from populations from India in the incidence of MDR1 common variants and haplotypes.

AB - The genetic variability, haplotype profile and ethnic differences of MDR1 polymorphisms in healthy Roma and Hungarian populations were analyzed and the results were compared with those of other populations available from the literature. Healthy subjects (465 Roma and 503 Hungarian) were genotyped for C1236T, G2677T/A and C3435T variants of MDR1 by PCR-RFLP assay. Differences were found between the Roma and Hungarian populations in the frequencies of MDR1 1236 CC (20.7 vs. 33.2%) and TT genotypes (30.8 vs. 21.9%), in T allele frequency (0.551 vs. 0.443) (p <0.002), and in 3435T allele frequency (0.482 vs. 0.527, p <0.04). Furthermore, the frequency of CGC, CGT and CTT haplotypes was significantly higher in the Hungarian population than in Roma (41.4 vs. 35.3%, 9.04 vs. 6.02% and 2.88 vs. 1.08%, respectively; p <0.009), whereas the frequency of TGC and TTC haplotypes was higher in the Roma population than in the Hungarian (7.31 vs. 1.68% and 6.67 vs. 2.08%, respectively; p <0.001). The prevalence of MDR1 polymorphisms in the Hungarian population is similar to that of other European populations; however, some differences were observed in the haplotype structures. In contrast, the Roma population differs from Hungarians, from Caucasians and from populations from India in the incidence of MDR1 common variants and haplotypes.

KW - C1236T

KW - C3435T

KW - G2677T/A

KW - Haplotype profile

KW - Hungarian

KW - Interethnic differences

KW - MDR1 (ABCB1)

KW - Roma

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U2 - 10.2133/dmpk.DMPK-10-SC-068

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C2 - 21178299

AN - SCOPUS:79955738661

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JO - Drug Metabolism and Pharmacokinetics

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