Genetic polymorphisms of human β-defensins in patients with ischemic stroke

Z. Tiszlavicz, F. Somogyvári, Z. Szolnoki, L. K. Sztriha, B. Németh, L. Vécsei, Y. Mándi

Research output: Article

9 Citations (Scopus)

Abstract

Objectives and Methods- Genetic predisposition of the inflammatory host response may affect the development of stroke. On the basis of the theory of infectious burden and risk of stroke, we considered it of interest to investigate the relevance of the single-nucleotide polymorphisms (SNPs) in the DEFB1 gene and the copy number variant (CNV) of the DEFB4 genes in ischemic stroke. Results- There were no significant differences in the genotype frequencies of the three SNPs of the DEFB1 gene between the patients with stroke (n=312) and the healthy blood donors (n=221). However, a higher frequency of a lower (

Original languageEnglish
Pages (from-to)109-115
Number of pages7
JournalActa Neurologica Scandinavica
Volume126
Issue number2
DOIs
Publication statusPublished - aug. 2012

Fingerprint

Defensins
Genetic Polymorphisms
Stroke
Single Nucleotide Polymorphism
Gene Dosage
Genetic Predisposition to Disease
Blood Donors
Genes
Genotype

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Genetic polymorphisms of human β-defensins in patients with ischemic stroke. / Tiszlavicz, Z.; Somogyvári, F.; Szolnoki, Z.; Sztriha, L. K.; Németh, B.; Vécsei, L.; Mándi, Y.

In: Acta Neurologica Scandinavica, Vol. 126, No. 2, 08.2012, p. 109-115.

Research output: Article

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