Genetikai polimorfizmusok mint a terápiás válasz prediktorai hepatitis C-vírus-fertozésben

Research output: Article

2 Citations (Scopus)

Abstract

The review discusses the genetic polymorphisms involved in the pathogenesis of hepatitis C virus (HCV) infection, that may determine the outcome of disease. In this field earlier both certain major histocompatibility complex (MHC) alleles and some cytokine gene variants have also been studied. Recently, the genome-wide association study (GWAS) and targeted single nucleotide polymorphism (SNP) analysis have revealed that a variant in the promoter region of interleukin-28B (IL-28B) gene is strongly linked to viral clearance and it may be the strongest pretreatment predictor of treatment response in chronic hepatitis C. Last year it was shown that two genetic variants leading to inosine triphosphatase deficiency protect against haemolytic anemia in patients receiving ribavirin during antiviral treatment for chronic HCV infection.

Original languageHungarian
Pages (from-to)876-881
Number of pages6
JournalOrvosi hetilap
Volume152
Issue number22
DOIs
Publication statusPublished - máj. 1 2011

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Keywords

  • ITPA defi ciency
  • MHC alleles
  • antiviral treatment
  • cytokine gene polymorphisms
  • hepatitis C virus
  • viral elimination

ASJC Scopus subject areas

  • Medicine(all)

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