Genetic impact dominates over environmental effects in development of carotid artery stiffness: A twin study

Tamás Horváth, J. Osztovits, Alexandra Pintér, Levente Littvay, Domonkos Cseh, Ádám D. Tárnoki, Dávid L. Tárnoki, Ádám L. Jermendy, Rita Steinbach, J. Métneki, Giuseppe Schillaci, M. Kollai, G. Jermendy

Research output: Article

3 Citations (Scopus)

Abstract

Arterial stiffness is an independent predictor of cardiovascular, cerebrovascular and all-cause mortality. Quantifying the genetic influence on the stiff arterial phenotype allows us to better predict the development of arterial stiffness. In this study, we aimed to determine the heritability of carotid artery stiffness in healthy twins. We studied 98 twin pairs of both sexes. We determined carotid artery stiffness locally using echo tracking and applanation tonometry. We estimated the heritability of stiffness parameters using structural equation modeling. The carotid distensibility coefficient showed the highest heritability (64%, 95% confidence interval 45-77%). The incremental elastic modulus, compliance and stiffness index β also showed substantial heritability (62%, 61% and 58%, respectively). The remaining 36-42% phenotypic variance was attributed to unshared environmental effects. Genetic influence appears to dominate over environmental factors in the development of carotid artery stiffness. Environmental factors may have an important role in favorably influencing the genetic predisposition for accelerated arterial stiffening.

Original languageEnglish
Pages (from-to)88-93
Number of pages6
JournalHypertension Research
Volume37
Issue number1
DOIs
Publication statusPublished - 2014

Fingerprint

Twin Studies
Carotid Arteries
Vascular Stiffness
Elastic Modulus
Manometry
Genetic Predisposition to Disease
Compliance
Confidence Intervals
Phenotype
Mortality

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Genetic impact dominates over environmental effects in development of carotid artery stiffness : A twin study. / Horváth, Tamás; Osztovits, J.; Pintér, Alexandra; Littvay, Levente; Cseh, Domonkos; Tárnoki, Ádám D.; Tárnoki, Dávid L.; Jermendy, Ádám L.; Steinbach, Rita; Métneki, J.; Schillaci, Giuseppe; Kollai, M.; Jermendy, G.

In: Hypertension Research, Vol. 37, No. 1, 2014, p. 88-93.

Research output: Article

Horváth, T, Osztovits, J, Pintér, A, Littvay, L, Cseh, D, Tárnoki, ÁD, Tárnoki, DL, Jermendy, ÁL, Steinbach, R, Métneki, J, Schillaci, G, Kollai, M & Jermendy, G 2014, 'Genetic impact dominates over environmental effects in development of carotid artery stiffness: A twin study', Hypertension Research, vol. 37, no. 1, pp. 88-93. https://doi.org/10.1038/hr.2013.133
Horváth, Tamás ; Osztovits, J. ; Pintér, Alexandra ; Littvay, Levente ; Cseh, Domonkos ; Tárnoki, Ádám D. ; Tárnoki, Dávid L. ; Jermendy, Ádám L. ; Steinbach, Rita ; Métneki, J. ; Schillaci, Giuseppe ; Kollai, M. ; Jermendy, G. / Genetic impact dominates over environmental effects in development of carotid artery stiffness : A twin study. In: Hypertension Research. 2014 ; Vol. 37, No. 1. pp. 88-93.
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