Genetic basis of tobacco smoking: Strong association of a specifc major histocompatibility complex haplotype on chromosome 6 with smoking behavior

G. Füst, Gudmundur J. Arason, J. Krámer, C. Szalai, J. Duba, Yan Yang, Erwin K. Chung, Bi Zhou, Carol A. Blanchong, Marja Liisa Lokki, Sigurdur Bödvarsson, Z. Prohászka, I. Karádi, Ágnes Vatay, M. Kovács, László Romics, Gudmundur Thorgeirsson, C. Yung Yu

Research output: Article

28 Citations (Scopus)

Abstract

The genetic basis for addiction to tobacco smoking - particularly that of the perception of olfactory stimuli that may be important in reinforcing smoking addiction - is largely unknown. A cluster of genes for olfactory receptors is in close proximity to the MHC region on chromosome 6. Polymorphisms of MHC class III genes (RCCX modules, TNFA promoter polymorphisms) were determined in 101 healthy subjects and 232 coronary artery disease (CAD) patients from Hungary with defined tobacco smoking habits. A highly significant association between ever smoking (past + current smokers) and a specific MHC haplotype was observed (odds ratios = 2.14-4.13; P-values = 0.012 to

Original languageEnglish
Pages (from-to)1507-1514
Number of pages8
JournalInternational Immunology
Volume16
Issue number10
DOIs
Publication statusPublished - okt. 2004

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Chromosomes, Human, Pair 6
Major Histocompatibility Complex
Haplotypes
Smoking
Olfactory Perception
Odorant Receptors
Hungary
Gene Regulatory Networks
Multigene Family
Habits
Coronary Artery Disease
Healthy Volunteers
Odds Ratio

ASJC Scopus subject areas

  • Immunology

Cite this

Genetic basis of tobacco smoking : Strong association of a specifc major histocompatibility complex haplotype on chromosome 6 with smoking behavior. / Füst, G.; Arason, Gudmundur J.; Krámer, J.; Szalai, C.; Duba, J.; Yang, Yan; Chung, Erwin K.; Zhou, Bi; Blanchong, Carol A.; Lokki, Marja Liisa; Bödvarsson, Sigurdur; Prohászka, Z.; Karádi, I.; Vatay, Ágnes; Kovács, M.; Romics, László; Thorgeirsson, Gudmundur; Yu, C. Yung.

In: International Immunology, Vol. 16, No. 10, 10.2004, p. 1507-1514.

Research output: Article

Füst, G. ; Arason, Gudmundur J. ; Krámer, J. ; Szalai, C. ; Duba, J. ; Yang, Yan ; Chung, Erwin K. ; Zhou, Bi ; Blanchong, Carol A. ; Lokki, Marja Liisa ; Bödvarsson, Sigurdur ; Prohászka, Z. ; Karádi, I. ; Vatay, Ágnes ; Kovács, M. ; Romics, László ; Thorgeirsson, Gudmundur ; Yu, C. Yung. / Genetic basis of tobacco smoking : Strong association of a specifc major histocompatibility complex haplotype on chromosome 6 with smoking behavior. In: International Immunology. 2004 ; Vol. 16, No. 10. pp. 1507-1514.
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