Genetic background of high blood pressure is associated with reduced mortality in premature neonates

Wolfgang Göpel, Mirja Müller, Heike Rabe, Johannes Borgmann, Tanja K. Rausch, Kirstin Faust, Angela Kribs, Jörg Dötsch, David Ellinghaus, Christoph Härtel, Claudia Roll, Miklos Szabo, Peter Nürnberg, Andre Franke, Inke R. König, Mark A. Turner, Egbert Herting

Research output: Article

2 Citations (Scopus)

Abstract

Objective: The aim of our study was to determine if a genetic background of high blood pressure is a survival factor in preterm infants. Design Prospective cohort study. Setting Patients were enrolled in 53 neonatal intensive care units. Patients Preterm infants with a birth weight below 1500 g. Exposures Genetic score blood pressure estimates were calculated based on adult data. We compared infants with high genetic blood pressure estimates (>75th percentile of the genetic score) to infants with low genetic blood pressure estimates (<25th percentile of the genetic score). Main outcome measures Lowest blood pressure on the first day of life and mortality. Results: 5580 preterm infants with a mean gestational age of 28.1±2.2 weeks and a mean birth weight of 1022±299 g were genotyped and analysed. Infants with low genetic blood pressure estimates had significantly lower blood pressure if compared with infants with high genetic blood pressure estimates (27.3±6.2vs 27.9±6.4, p=0.009, t-test). Other risk factors for low blood pressure included low gestational age (-1.26 mm Hg/week) and mechanical ventilation (-2.24 mm Hg, p<0.001 for both variables, linear regression analysis). Mortality was significantly reduced in infants with high genetic blood pressure estimates (28-day mortality: 21/1395, 1.5% vs 44/1395, 3.2%, p=0.005, Fisher's exact test). This survival advantage was independent of treatment with catecholamines. Conclusions Our study provides first evidence that a genetic background of high blood pressure may be beneficial with regard to survival of preterm infants.

Original languageEnglish
Pages (from-to)F184-F189
JournalArchives of Disease in Childhood: Fetal and Neonatal Edition
Volume105
Issue number2
DOIs
Publication statusPublished - márc. 1 2020

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

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    Göpel, W., Müller, M., Rabe, H., Borgmann, J., Rausch, T. K., Faust, K., Kribs, A., Dötsch, J., Ellinghaus, D., Härtel, C., Roll, C., Szabo, M., Nürnberg, P., Franke, A., König, I. R., Turner, M. A., & Herting, E. (2020). Genetic background of high blood pressure is associated with reduced mortality in premature neonates. Archives of Disease in Childhood: Fetal and Neonatal Edition, 105(2), F184-F189. https://doi.org/10.1136/archdischild-2019-317131