Genes encoding cuticular proteins are components of the Nimrod gene cluster in Drosophila

Gyöngyi Cinege, János Zsámboki, Maite Vidal-Quadras, Anne Uv, Gábor Csordás, Viktor Honti, Erika Gábor, Z. Hegedűs, Gergely I.B. Varga, A. Kovács, G. Juhász, Michael J. Williams, I. Andó, E. Kurucz

Research output: Article

3 Citations (Scopus)

Abstract

The Nimrod gene cluster, located on the second chromosome of Drosophila melanogaster, is the largest synthenic unit of the Drosophila genome. Nimrod genes show blood cell specific expression and code for phagocytosis receptors that play a major role in fruit fly innate immune functions. We previously identified three homologous genes (vajk-1, vajk-2 and vajk-3) located within the Nimrod cluster, which are unrelated to the Nimrod genes, but are homologous to a fourth gene (vajk-4) located outside the cluster. Here we show that, unlike the Nimrod candidates, the Vajk proteins are expressed in cuticular structures of the late embryo and the late pupa, indicating that they contribute to cuticular barrier functions.

Original languageEnglish
Pages (from-to)45-54
Number of pages10
JournalInsect Biochemistry and Molecular Biology
Volume87
DOIs
Publication statusPublished - aug. 1 2017

Fingerprint

Gene encoding
Multigene Family
multigene family
Drosophila
Genes
Proteins
genes
proteins
fruit flies
blood cells
phagocytosis
Pupa
Drosophila melanogaster
pupae
Chromosomes
Fruits
Fruit
Blood Cells
chromosomes
Embryonic Structures

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Insect Science

Cite this

Genes encoding cuticular proteins are components of the Nimrod gene cluster in Drosophila. / Cinege, Gyöngyi; Zsámboki, János; Vidal-Quadras, Maite; Uv, Anne; Csordás, Gábor; Honti, Viktor; Gábor, Erika; Hegedűs, Z.; Varga, Gergely I.B.; Kovács, A.; Juhász, G.; Williams, Michael J.; Andó, I.; Kurucz, E.

In: Insect Biochemistry and Molecular Biology, Vol. 87, 01.08.2017, p. 45-54.

Research output: Article

Cinege, Gyöngyi ; Zsámboki, János ; Vidal-Quadras, Maite ; Uv, Anne ; Csordás, Gábor ; Honti, Viktor ; Gábor, Erika ; Hegedűs, Z. ; Varga, Gergely I.B. ; Kovács, A. ; Juhász, G. ; Williams, Michael J. ; Andó, I. ; Kurucz, E. / Genes encoding cuticular proteins are components of the Nimrod gene cluster in Drosophila. In: Insect Biochemistry and Molecular Biology. 2017 ; Vol. 87. pp. 45-54.
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AU - Uv, Anne

AU - Csordás, Gábor

AU - Honti, Viktor

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AU - Hegedűs, Z.

AU - Varga, Gergely I.B.

AU - Kovács, A.

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AU - Williams, Michael J.

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AU - Kurucz, E.

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KW - Gene cluster

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