Gene-environmental effects behind leukoaraiosis: a silent genetic variant of the kinesin protein can be activated in a subject with poorly controlled long-lasting hypertension

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4 Citations (Scopus)

Abstract

Objectives: The rs8702 variant of the kinesin light chain 1 was earlier found to be a risk factor for vascular white matter demyelinization, referred to as leukoaraiosis (LA), in hypertensive smokers. The aim of this study was to determine the extent to which this genetic variant gives rise to the occurrence of LA and its severity, if the subject is exposed to long-lasting, severe and poorly controlled hypertension. Design and methods: The clinical and genetic data on 204 LA patients without infarction and 240 neuroimaging alteration-free subjects were analyzed. Results: The rs8702 CC genotype proved to exert strong amplifying effects on the occurrence and severity of LA in patients with long-lasting poorly controlled severe hypertension (a 25.9-fold risk of LA in carriers relative to non-carriers; p <0.001). Conclusion: The previous data on hypertensive smokers and the present findings suggest that the rs8702 CC variant is increasingly unfavorable as regards LA if the hypertension is more severe and poorly controlled. This draws attention to a need for stricter preventive measures in CC carriers.

Original languageEnglish
Pages (from-to)630-633
Number of pages4
JournalClinical Biochemistry
Volume42
Issue number7-8
DOIs
Publication statusPublished - máj. 2009

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Leukoaraiosis
Kinesin
Environmental impact
Genes
Neuroimaging
Hypertension
Proteins
Infarction
Blood Vessels
Genotype
Light

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

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title = "Gene-environmental effects behind leukoaraiosis: a silent genetic variant of the kinesin protein can be activated in a subject with poorly controlled long-lasting hypertension",
abstract = "Objectives: The rs8702 variant of the kinesin light chain 1 was earlier found to be a risk factor for vascular white matter demyelinization, referred to as leukoaraiosis (LA), in hypertensive smokers. The aim of this study was to determine the extent to which this genetic variant gives rise to the occurrence of LA and its severity, if the subject is exposed to long-lasting, severe and poorly controlled hypertension. Design and methods: The clinical and genetic data on 204 LA patients without infarction and 240 neuroimaging alteration-free subjects were analyzed. Results: The rs8702 CC genotype proved to exert strong amplifying effects on the occurrence and severity of LA in patients with long-lasting poorly controlled severe hypertension (a 25.9-fold risk of LA in carriers relative to non-carriers; p <0.001). Conclusion: The previous data on hypertensive smokers and the present findings suggest that the rs8702 CC variant is increasingly unfavorable as regards LA if the hypertension is more severe and poorly controlled. This draws attention to a need for stricter preventive measures in CC carriers.",
keywords = "Gene, Gene-environmental interaction, Genetic variant, Kinesin, Leukoaraiosis, White matter damage",
author = "Z. Szolnoki and A. Kondacs and Y. M{\'a}ndi and F. Somogyv{\'a}ri",
year = "2009",
month = "5",
doi = "10.1016/j.clinbiochem.2008.11.003",
language = "English",
volume = "42",
pages = "630--633",
journal = "Clinical Biochemistry",
issn = "0009-9120",
publisher = "Elsevier Inc.",
number = "7-8",

}

TY - JOUR

T1 - Gene-environmental effects behind leukoaraiosis

T2 - a silent genetic variant of the kinesin protein can be activated in a subject with poorly controlled long-lasting hypertension

AU - Szolnoki, Z.

AU - Kondacs, A.

AU - Mándi, Y.

AU - Somogyvári, F.

PY - 2009/5

Y1 - 2009/5

N2 - Objectives: The rs8702 variant of the kinesin light chain 1 was earlier found to be a risk factor for vascular white matter demyelinization, referred to as leukoaraiosis (LA), in hypertensive smokers. The aim of this study was to determine the extent to which this genetic variant gives rise to the occurrence of LA and its severity, if the subject is exposed to long-lasting, severe and poorly controlled hypertension. Design and methods: The clinical and genetic data on 204 LA patients without infarction and 240 neuroimaging alteration-free subjects were analyzed. Results: The rs8702 CC genotype proved to exert strong amplifying effects on the occurrence and severity of LA in patients with long-lasting poorly controlled severe hypertension (a 25.9-fold risk of LA in carriers relative to non-carriers; p <0.001). Conclusion: The previous data on hypertensive smokers and the present findings suggest that the rs8702 CC variant is increasingly unfavorable as regards LA if the hypertension is more severe and poorly controlled. This draws attention to a need for stricter preventive measures in CC carriers.

AB - Objectives: The rs8702 variant of the kinesin light chain 1 was earlier found to be a risk factor for vascular white matter demyelinization, referred to as leukoaraiosis (LA), in hypertensive smokers. The aim of this study was to determine the extent to which this genetic variant gives rise to the occurrence of LA and its severity, if the subject is exposed to long-lasting, severe and poorly controlled hypertension. Design and methods: The clinical and genetic data on 204 LA patients without infarction and 240 neuroimaging alteration-free subjects were analyzed. Results: The rs8702 CC genotype proved to exert strong amplifying effects on the occurrence and severity of LA in patients with long-lasting poorly controlled severe hypertension (a 25.9-fold risk of LA in carriers relative to non-carriers; p <0.001). Conclusion: The previous data on hypertensive smokers and the present findings suggest that the rs8702 CC variant is increasingly unfavorable as regards LA if the hypertension is more severe and poorly controlled. This draws attention to a need for stricter preventive measures in CC carriers.

KW - Gene

KW - Gene-environmental interaction

KW - Genetic variant

KW - Kinesin

KW - Leukoaraiosis

KW - White matter damage

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