Abstract
Objectives: The rs8702 variant of the kinesin light chain 1 was earlier found to be a risk factor for vascular white matter demyelinization, referred to as leukoaraiosis (LA), in hypertensive smokers. The aim of this study was to determine the extent to which this genetic variant gives rise to the occurrence of LA and its severity, if the subject is exposed to long-lasting, severe and poorly controlled hypertension. Design and methods: The clinical and genetic data on 204 LA patients without infarction and 240 neuroimaging alteration-free subjects were analyzed. Results: The rs8702 CC genotype proved to exert strong amplifying effects on the occurrence and severity of LA in patients with long-lasting poorly controlled severe hypertension (a 25.9-fold risk of LA in carriers relative to non-carriers; p <0.001). Conclusion: The previous data on hypertensive smokers and the present findings suggest that the rs8702 CC variant is increasingly unfavorable as regards LA if the hypertension is more severe and poorly controlled. This draws attention to a need for stricter preventive measures in CC carriers.
| Original language | English |
|---|---|
| Pages (from-to) | 630-633 |
| Number of pages | 4 |
| Journal | Clinical Biochemistry |
| Volume | 42 |
| Issue number | 7-8 |
| DOIs | |
| Publication status | Published - máj. 2009 |
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ASJC Scopus subject areas
- Clinical Biochemistry
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Gene-environmental effects behind leukoaraiosis : a silent genetic variant of the kinesin protein can be activated in a subject with poorly controlled long-lasting hypertension. / Szolnoki, Z.; Kondacs, A.; Mándi, Y.; Somogyvári, F.
In: Clinical Biochemistry, Vol. 42, No. 7-8, 05.2009, p. 630-633.Research output: Article
}
TY - JOUR
T1 - Gene-environmental effects behind leukoaraiosis
T2 - a silent genetic variant of the kinesin protein can be activated in a subject with poorly controlled long-lasting hypertension
AU - Szolnoki, Z.
AU - Kondacs, A.
AU - Mándi, Y.
AU - Somogyvári, F.
PY - 2009/5
Y1 - 2009/5
N2 - Objectives: The rs8702 variant of the kinesin light chain 1 was earlier found to be a risk factor for vascular white matter demyelinization, referred to as leukoaraiosis (LA), in hypertensive smokers. The aim of this study was to determine the extent to which this genetic variant gives rise to the occurrence of LA and its severity, if the subject is exposed to long-lasting, severe and poorly controlled hypertension. Design and methods: The clinical and genetic data on 204 LA patients without infarction and 240 neuroimaging alteration-free subjects were analyzed. Results: The rs8702 CC genotype proved to exert strong amplifying effects on the occurrence and severity of LA in patients with long-lasting poorly controlled severe hypertension (a 25.9-fold risk of LA in carriers relative to non-carriers; p <0.001). Conclusion: The previous data on hypertensive smokers and the present findings suggest that the rs8702 CC variant is increasingly unfavorable as regards LA if the hypertension is more severe and poorly controlled. This draws attention to a need for stricter preventive measures in CC carriers.
AB - Objectives: The rs8702 variant of the kinesin light chain 1 was earlier found to be a risk factor for vascular white matter demyelinization, referred to as leukoaraiosis (LA), in hypertensive smokers. The aim of this study was to determine the extent to which this genetic variant gives rise to the occurrence of LA and its severity, if the subject is exposed to long-lasting, severe and poorly controlled hypertension. Design and methods: The clinical and genetic data on 204 LA patients without infarction and 240 neuroimaging alteration-free subjects were analyzed. Results: The rs8702 CC genotype proved to exert strong amplifying effects on the occurrence and severity of LA in patients with long-lasting poorly controlled severe hypertension (a 25.9-fold risk of LA in carriers relative to non-carriers; p <0.001). Conclusion: The previous data on hypertensive smokers and the present findings suggest that the rs8702 CC variant is increasingly unfavorable as regards LA if the hypertension is more severe and poorly controlled. This draws attention to a need for stricter preventive measures in CC carriers.
KW - Gene
KW - Gene-environmental interaction
KW - Genetic variant
KW - Kinesin
KW - Leukoaraiosis
KW - White matter damage
UR - http://www.scopus.com/inward/record.url?scp=63649091664&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=63649091664&partnerID=8YFLogxK
U2 - 10.1016/j.clinbiochem.2008.11.003
DO - 10.1016/j.clinbiochem.2008.11.003
M3 - Article
C2 - 19046961
AN - SCOPUS:63649091664
VL - 42
SP - 630
EP - 633
JO - Clinical Biochemistry
JF - Clinical Biochemistry
SN - 0009-9120
IS - 7-8
ER -