Újszülöttkori cytomegalovirus-fertozés kezelése ganciclovirrel

Ágnes Till, Barnabás Rózsai, Nóra Kovács, Judit Storcz, Ferenc Somogyvári, Judit Deák, Tibor Ertl, Tamás Decsi

Research output: Article

3 Citations (Scopus)

Abstract

The authors present the cases of two infants with congenital cytomegalovirus infection, who to the best of the authors'knowledge were the first ones to receive ganciclovir treatment in Hungary. Both infants were treated for symptomatic congenital cytomegalovirus infection affecting the central nervous system. Ganciclovir was given intravenously in two phases, for a total of 4 and 6 weeks, in a daily dose of 5-10 mg/kg. Diagnosis of infection and follow-up of treatment efficacy was based on the quantitative assesment by PCR assay of viral nucleic acid in blood and urine samples. Treatment resulted in substantial reduction of viral copy numbers in both infants' blood and urine samples. Improvement in the biochemical markers of disease activity was accompanied with spectacular improvement of clinical symptoms in the infant with severe liver involvement. Following the treatment viral loads increased in both infant but clinical symptoms did not reoccur. In one patient a considerable improvement of hearing loss was observed. The authors' first results indicate that ganciclovir treatment of neonatal cytomegalovirus infection represents a promising approach in preventing the progression of the disease and in ameliorating the cosequences.

Translated title of the contributionGanciclovir treatment of congenital cytomegalovirus infection
Original languageHungarian
Pages (from-to)609-612
Number of pages4
JournalOrvosi hetilap
Volume147
Issue number13
Publication statusPublished - ápr. 2 2006

Keywords

  • Congenital cytomegalovirus infection
  • Ganciclovir
  • Quantitative PCR

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Till, Á., Rózsai, B., Kovács, N., Storcz, J., Somogyvári, F., Deák, J., Ertl, T., & Decsi, T. (2006). Újszülöttkori cytomegalovirus-fertozés kezelése ganciclovirrel. Orvosi hetilap, 147(13), 609-612.