Galanin and its three receptors in human pituitary adenoma

Roshan Tofighi, Swapnali Barde, Miklos Palkovits, Anders Höög, Tomas Hökfelt, Sandra Ceccatelli, Anna Lena Hulting

Research output: Article

7 Citations (Scopus)

Abstract

Galanin, a 29-aminoacid peptide (30 in humans), is widely distributed in the nervous and endocrine systems and exerts its actions via three G-protein-coupled receptors, GalR1-3. The galanin system has, among others, been associated with tumorigenesis. Our objective was to assess the expression of galanin and its receptors in pituitary tumors. Transcript levels of galanin and galanin receptors 1-3 (GalR1-3) were measured using quantitative real-time PCR (q-PCR) in pituitary tumors, surgically removed from thirteen patients, and twelve post mortem pituitaries. Galanin, GalR1 and GalR2 mRNA, but not GalR3 mRNA, were found in the twelve human post-mortem pituitaries. Expression of GalR1 was relatively increased in most, whereas GalR2 was decreased in some tumors. High levels of GalR3 were only found in tumors of five patients, who all relapsed shortly after surgical intervention. The results suggest that GalR3, a receptor for the neuroendocrine peptide galanin, is a potential marker for relapsing pituitary tumors. Thus, galanin receptors may play an important role in pituitary tumors, also for surgical outcome and prognosis, and may serve as a diagnostic tool. The association of GalR3 with tumor relapse suggests that antagonists to this receptor represent a potential therapeutic approach to treatment of pituitary tumors.

Original languageEnglish
Pages (from-to)195-201
Number of pages7
JournalNeuropeptides
Volume46
Issue number5
DOIs
Publication statusPublished - okt. 1 2012

ASJC Scopus subject areas

  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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  • Cite this

    Tofighi, R., Barde, S., Palkovits, M., Höög, A., Hökfelt, T., Ceccatelli, S., & Hulting, A. L. (2012). Galanin and its three receptors in human pituitary adenoma. Neuropeptides, 46(5), 195-201. https://doi.org/10.1016/j.npep.2012.07.003