From neurophysiology to genetics: Cortical information processing in migraine underlies familial influences - A novel approach

P. S. Sándor, J. Áfra, A. P. Cecchini, A. Albert, J. Schoenen

Research output: Article

13 Citations (Scopus)


Migraine patients show impaired cortical information processing between attacks with deficient habituation of pattern-reversal visual evoked potentials (VEP), and strong intensity dependence of auditory cortical evoked potentials (IDAP). This could be a genetic trait as certain genetic patterns are known for evoked potentials in healthy subjects. VEP-habituation and IDAP were studied in 40 migraine patients, i.e. pairs of 20 parents and their children. We developed a novel approach based on Monte Carlo statistics to selectively assess vertical familial influences. Both groups, parents and children, were characterized by abnormal VEP-habituation and IDAP. However, similarity between related pairs was far more pronounced than similarity between unrelated pairs. Assessed with a novel statistical approach, familial influences proved to be highly significant in determining cortical information processing in migraineurs, thus supporting the important role of genetic factors.

Original languageEnglish
Pages (from-to)68-72
Number of pages5
JournalFunctional neurology
Issue number3 SUPPL.
Publication statusPublished - dec. 1 2000


ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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