Introduction - In a study of 125 multiple myeloma patients authors found a fourty-fold increase of turnout incidence among the first-degree relatives compared to the normal population. The authors wanted to determine the causes of this high tumour risk. Patients and methods - The data of 111 patients were analysed in a retrospective study. Relationship between the blood groups, the type of myeloma and the tumour incidence were examined. Suppressor gene p53 mutation-analysis was performed in the case of 14 patients and 16 healthy first-degree relatives. Results - The distribution of different tumours in the study were not different from that found among the Hungarian population. There was no statistical relationship between the patients' blood group antigens and the tumour incidence. IgA occurred more frequently in the group of patients who developed other type of tumours during the course of the disease. Multiple myeloma patients who had previous or concomitant malignancies had poorer survival. Conclusions - Since the authors found no mutations in the exons 4-8 of the p53 suppressor gene in the families examined, they emphasize the need to elucidate the reasons for this extreme high risk for tumourgenesis. They also call for a cancer detection and prevention program concerning this group of people.
|Number of pages||5|
|Journal||Lege Artis Medicinae|
|Publication status||Published - szept. 30 2000|
- Familial incidence of tumours
- Multiple myeloma
- p53 suppressor gene
ASJC Scopus subject areas