Frequency of miscarriage/stillbirth and terminations of pregnancy among women with congenital heart disease in Germany, Hungary and Japan

Marc André Koerten, Koichiro Niwa, A. Szatmári, Balint Hajnalka, Zoltán Ruzsa, Nicole Nagdyman, Eva Niggemeyer, Brigitte Peters, Karl Theodor M Schneider, Bettina Kuschel, Yoshiko Mizuno, Felix Berger, Harald Kaemmerer, Ulrike M M Bauer

Research output: Article

5 Citations (Scopus)

Abstract

Background: The 2011 guidelines of the European Society of Cardiology (ESC) on the management of cardiovascular diseases during pregnancy define the maternal predictors for neonatal complications. The aim of this study was to determine whether these are associated with an increased number of miscarriages/stillbirths and terminations of pregnancy (TOPs) also in patients with congenital heart defects (CHD). Methods and Results: The 634 women from Germany, Hungary and Japan were surveyed concerning the issues of sexuality and reproductive health, as well as their general life situation and medical care. 25% of the recorded pregnancies in women with CHD resulted in miscarriage, stillbirth or TOP. Affecting 16.8% of all recorded pregnancies, miscarriages or stillbirths occurred more frequently than in the general population and more than previously recorded for patients with CHD. TOP occurred in 8% of the surveyed pregnancies. Underlying maternal predictors for neonatal events had an influence on the number of TOP; among those with underlying predictors, TOP was recorded 3-fold more than in those without such predictors (15.6% vs. 5.5%). Remarkably, a significant deficit regarding the level of information on potential pregnancy-associated risks was observed in all 3 participating countries. Conclusions: Pregnant women with CHD should always be treated and counseled individually by cardiologists, gynecologists, obstetricians and anesthetists with appropriate expert knowledge.

Original languageEnglish
Pages (from-to)1846-1851
Number of pages6
JournalCirculation Journal
Volume80
Issue number8
DOIs
Publication statusPublished - 2016

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Stillbirth
Hungary
Spontaneous Abortion
Germany
Heart Diseases
Japan
Pregnancy
Congenital Heart Defects
Mothers
Reproductive Health
Sexuality
Pregnant Women
Cardiovascular Diseases
Guidelines

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Frequency of miscarriage/stillbirth and terminations of pregnancy among women with congenital heart disease in Germany, Hungary and Japan. / Koerten, Marc André; Niwa, Koichiro; Szatmári, A.; Hajnalka, Balint; Ruzsa, Zoltán; Nagdyman, Nicole; Niggemeyer, Eva; Peters, Brigitte; Schneider, Karl Theodor M; Kuschel, Bettina; Mizuno, Yoshiko; Berger, Felix; Kaemmerer, Harald; Bauer, Ulrike M M.

In: Circulation Journal, Vol. 80, No. 8, 2016, p. 1846-1851.

Research output: Article

Koerten, MA, Niwa, K, Szatmári, A, Hajnalka, B, Ruzsa, Z, Nagdyman, N, Niggemeyer, E, Peters, B, Schneider, KTM, Kuschel, B, Mizuno, Y, Berger, F, Kaemmerer, H & Bauer, UMM 2016, 'Frequency of miscarriage/stillbirth and terminations of pregnancy among women with congenital heart disease in Germany, Hungary and Japan', Circulation Journal, vol. 80, no. 8, pp. 1846-1851. https://doi.org/10.1253/circj.CJ-15-1296
Koerten, Marc André ; Niwa, Koichiro ; Szatmári, A. ; Hajnalka, Balint ; Ruzsa, Zoltán ; Nagdyman, Nicole ; Niggemeyer, Eva ; Peters, Brigitte ; Schneider, Karl Theodor M ; Kuschel, Bettina ; Mizuno, Yoshiko ; Berger, Felix ; Kaemmerer, Harald ; Bauer, Ulrike M M. / Frequency of miscarriage/stillbirth and terminations of pregnancy among women with congenital heart disease in Germany, Hungary and Japan. In: Circulation Journal. 2016 ; Vol. 80, No. 8. pp. 1846-1851.
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AU - Koerten, Marc André

AU - Niwa, Koichiro

AU - Szatmári, A.

AU - Hajnalka, Balint

AU - Ruzsa, Zoltán

AU - Nagdyman, Nicole

AU - Niggemeyer, Eva

AU - Peters, Brigitte

AU - Schneider, Karl Theodor M

AU - Kuschel, Bettina

AU - Mizuno, Yoshiko

AU - Berger, Felix

AU - Kaemmerer, Harald

AU - Bauer, Ulrike M M

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AB - Background: The 2011 guidelines of the European Society of Cardiology (ESC) on the management of cardiovascular diseases during pregnancy define the maternal predictors for neonatal complications. The aim of this study was to determine whether these are associated with an increased number of miscarriages/stillbirths and terminations of pregnancy (TOPs) also in patients with congenital heart defects (CHD). Methods and Results: The 634 women from Germany, Hungary and Japan were surveyed concerning the issues of sexuality and reproductive health, as well as their general life situation and medical care. 25% of the recorded pregnancies in women with CHD resulted in miscarriage, stillbirth or TOP. Affecting 16.8% of all recorded pregnancies, miscarriages or stillbirths occurred more frequently than in the general population and more than previously recorded for patients with CHD. TOP occurred in 8% of the surveyed pregnancies. Underlying maternal predictors for neonatal events had an influence on the number of TOP; among those with underlying predictors, TOP was recorded 3-fold more than in those without such predictors (15.6% vs. 5.5%). Remarkably, a significant deficit regarding the level of information on potential pregnancy-associated risks was observed in all 3 participating countries. Conclusions: Pregnant women with CHD should always be treated and counseled individually by cardiologists, gynecologists, obstetricians and anesthetists with appropriate expert knowledge.

KW - Adult congenital heart disease

KW - Miscarriage

KW - Neonatal complications

KW - Pregnancy

KW - Stillbirth

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