Fetal pituitary graft is capable of initiating hormone synthesis in median eminence removed adult rat.

A. Nemeskéri, G. Sétáló, B. Kacsóh, B. Halász

Research output: Article

2 Citations (Scopus)

Abstract

Rathke's pouches of 12- and 13-day-old rat embryos were implanted beneath the kidney capsule of adult male rats subjected to the removal of median eminence or to sham-operation. Host animals were sacrificed 28 days after grafting and the implanted pituitaries were processed for immunohistological examination. ACTH, LH-beta, FSH-beta, TSH-beta, GH and PRL immunopositive cells could be observed in fetal grafts of all experimental groups. However, the number and staining intensity of different hormone containing cells largely varied and presumably depended on the hormonal state of host animals. The results indicate that undifferentiated fetal pituitary does not require hypothalamic hypophysiotrophic neurohormones for proliferation and cytodifferentiation and that its development might be modulated by circulating trophic hormones of host animals.

Original languageEnglish
Pages (from-to)283-292
Number of pages10
JournalEndocrinologia experimentalis
Volume24
Issue number3
Publication statusPublished - szept. 1990

ASJC Scopus subject areas

  • Endocrinology

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