Fermented wheat germ extract (Avemar) inhibits adjuvant arthritis

Andras Telekes, Akos Resetar, G. Bálint, Gabor Blazso, G. Falkay, K. Lapis, E. Rásó, B. Szende, Michael Ehrenfeld, Yehuda Shoenfeld, M. Hídvégi

Research output: Conference contribution

11 Citations (Scopus)

Abstract

Anti-inflammatory efficacy of the fermented wheat germ extract (FWGE, Avemar) in the rat adjuvant arthritis (AA) model was examined. To Wistar rats with AA, different doses of FWGE and antiinflammatory drugs (indomethacin, dexamethasone) as monotherapies were administered and FWGE and either diclofenac or dexamethasone were also given in combination. Besides plethysmographies of the paws, histological investigations of synovial tissues were also performed along with detection of CD4+ and CD8+ T lymphocytes. Gene expressions of COX-1 and 2 were determined by real-time polymerase chain reaction (PCR). FWGE monotherapy significantly inhibited the development of the secondary (immune-mediated) response in AA, and dexamethasone and indomethacin exerted inhibitory effects in a degree comparable to that of FWGE. Histological analysis of the affected joints confirmed the results. FWGE inhibited COX-1 and -2, while indomethacin enhanced COX-2 gene expressions. FWGE had an additive interaction with diclofenac. It is concluded that FWGE has significant anti-inflammatory efficacy confirmed by plethysmography, histology, and real-time PCR.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages348-361
Number of pages14
Volume1110
DOIs
Publication statusPublished - szept. 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1110
ISSN (Print)00778923
ISSN (Electronic)17496632

Fingerprint

Experimental Arthritis
Indomethacin
Dexamethasone
Anti-Inflammatory Agents
Diclofenac
Polymerase chain reaction
Gene expression
Rats
Real-Time Polymerase Chain Reaction
Plethysmography
Gene Expression
Histology
T-cells
Wistar Rats
Joints
Tissue
T-Lymphocytes
Pharmaceutical Preparations
Avemar

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Telekes, A., Resetar, A., Bálint, G., Blazso, G., Falkay, G., Lapis, K., ... Hídvégi, M. (2007). Fermented wheat germ extract (Avemar) inhibits adjuvant arthritis. In Annals of the New York Academy of Sciences (Vol. 1110, pp. 348-361). (Annals of the New York Academy of Sciences; Vol. 1110). https://doi.org/10.1196/annals.1423.037

Fermented wheat germ extract (Avemar) inhibits adjuvant arthritis. / Telekes, Andras; Resetar, Akos; Bálint, G.; Blazso, Gabor; Falkay, G.; Lapis, K.; Rásó, E.; Szende, B.; Ehrenfeld, Michael; Shoenfeld, Yehuda; Hídvégi, M.

Annals of the New York Academy of Sciences. Vol. 1110 2007. p. 348-361 (Annals of the New York Academy of Sciences; Vol. 1110).

Research output: Conference contribution

Telekes, A, Resetar, A, Bálint, G, Blazso, G, Falkay, G, Lapis, K, Rásó, E, Szende, B, Ehrenfeld, M, Shoenfeld, Y & Hídvégi, M 2007, Fermented wheat germ extract (Avemar) inhibits adjuvant arthritis. in Annals of the New York Academy of Sciences. vol. 1110, Annals of the New York Academy of Sciences, vol. 1110, pp. 348-361. https://doi.org/10.1196/annals.1423.037
Telekes A, Resetar A, Bálint G, Blazso G, Falkay G, Lapis K et al. Fermented wheat germ extract (Avemar) inhibits adjuvant arthritis. In Annals of the New York Academy of Sciences. Vol. 1110. 2007. p. 348-361. (Annals of the New York Academy of Sciences). https://doi.org/10.1196/annals.1423.037
Telekes, Andras ; Resetar, Akos ; Bálint, G. ; Blazso, Gabor ; Falkay, G. ; Lapis, K. ; Rásó, E. ; Szende, B. ; Ehrenfeld, Michael ; Shoenfeld, Yehuda ; Hídvégi, M. / Fermented wheat germ extract (Avemar) inhibits adjuvant arthritis. Annals of the New York Academy of Sciences. Vol. 1110 2007. pp. 348-361 (Annals of the New York Academy of Sciences).
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