Female reproductive toxicology of cadmium

P. Massányi, N. Lukáč, V. Uhrín, R. Toman, J. Pivko, J. Rafay, Z. Forgács, Z. Somosy

Research output: Article

43 Citations (Scopus)

Abstract

The aim of this study was to determine effects of Cd on the structure of ovary, oviduct and uterus after an experimental administration. Animals were divided into three groups. In group A rabbits received cadmium i.p. and were killed after 48 h. In group C Cd was administered p.o. for 5 month. The group K was the control. Decreased relative volume of growing follicles and increased stroma after Cd administration were detected. The number of atretic follicles was significantly higher after administration of Cd. The most frequent ultrastructural alterations observed were undulation of external nuclear membrane, dilatation of perinuclear cistern and endoplasmic reticulum. In all studied types of cells mitochondria with altered structure were found. In the oviduct the highest amount of epithelium in the group with long-term Cd administration was found. Microscopic analysis showed oedematization of the oviduct tissue, caused by disintegration of the capillary wall. An electron microscopic analysis showed dilatation of perinuclear cistern. The intercellular spaces were enlarged and junctions between cells were affected. Mainly after a long-term cadmium administration nuclear chromatin disintegration was present. In the uterus a significant change was determined in the relative volume of glandular epithelium. Increase of stroma was a sign of uterus oedamatization caused by damage in the wall of blood vessels and subsequent diapedesis. After Cd administration alteration in uterus were less expressed, in comparison with ovary and oviduct. Alteration of nuclear chromatin contain following Cd administration suggests degenerative functional changes.

Original languageEnglish
Pages (from-to)287-299
Number of pages13
JournalActa Biologica Hungarica
Volume58
Issue number3
DOIs
Publication statusPublished - szept. 2007

Fingerprint

reproductive toxicology
Oviducts
toxicology
oviducts
Cadmium
Toxicology
uterus
Uterus
cadmium
Chromatin
chromatin
Dilatation
Ovary
epithelium
Epithelium
Transendothelial and Transepithelial Migration
Disintegration
follicular atresia
Ovarian Follicle
Intercellular Junctions

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Massányi, P., Lukáč, N., Uhrín, V., Toman, R., Pivko, J., Rafay, J., ... Somosy, Z. (2007). Female reproductive toxicology of cadmium. Acta Biologica Hungarica, 58(3), 287-299. https://doi.org/10.1556/ABiol.58.2007.3.5

Female reproductive toxicology of cadmium. / Massányi, P.; Lukáč, N.; Uhrín, V.; Toman, R.; Pivko, J.; Rafay, J.; Forgács, Z.; Somosy, Z.

In: Acta Biologica Hungarica, Vol. 58, No. 3, 09.2007, p. 287-299.

Research output: Article

Massányi, P, Lukáč, N, Uhrín, V, Toman, R, Pivko, J, Rafay, J, Forgács, Z & Somosy, Z 2007, 'Female reproductive toxicology of cadmium', Acta Biologica Hungarica, vol. 58, no. 3, pp. 287-299. https://doi.org/10.1556/ABiol.58.2007.3.5
Massányi P, Lukáč N, Uhrín V, Toman R, Pivko J, Rafay J et al. Female reproductive toxicology of cadmium. Acta Biologica Hungarica. 2007 szept.;58(3):287-299. https://doi.org/10.1556/ABiol.58.2007.3.5
Massányi, P. ; Lukáč, N. ; Uhrín, V. ; Toman, R. ; Pivko, J. ; Rafay, J. ; Forgács, Z. ; Somosy, Z. / Female reproductive toxicology of cadmium. In: Acta Biologica Hungarica. 2007 ; Vol. 58, No. 3. pp. 287-299.
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