Falls in spinocerebellar ataxias: Results of the EuroSCA fall study

Ella M.R. Fonteyn, Tanja Schmitz-Hübsch, Carla C. Verstappen, Laslo Baliko, Bastiaan R. Bloem, Silvia Boesch, Lisa Bunn, Perrine Charles, Alexandra Dürr, Allesandro Filla, Paola Giunti, Christoph Globas, Thomas Klockgether, Bela Melegh, Massimo Pandolfo, Anna De Rosa, Ludger Schöls, Dagmar Timmann, Marten Munneke, Berry P.H. KremerBart P.C. Van De Warrenburg

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To investigate the frequency, details, and consequences of falls in patients with autosomal dominant spinocerebellar ataxias (SCAs) and to derive specific disease-related risk factors that are associated with an increased fall frequency. Two hundred twenty-eight patients with SCA1, SCA2, SCA3, or SCA6, recruited from the EuroSCA natural history study, completed a fall questionnaire that assessed the frequency, consequences, and several details of falls in the previous 12 months. Relevant disease characteristics were retrieved from the EuroSCA registry. The database of the natural history study provided the ataxia severity scores as well as the number and nature of non-ataxia symptoms. Patients (73.6%) reported at least one fall in the preceding 12 months. There was a high rate of fall-related injuries (74%). Factors that were associated with a higher fall frequency included: disease duration, severity of ataxia, the presence of pyramidal symptoms, the total number of non-ataxia symptoms, and the genotype SCA3. Factors associated with a lower fall frequency were: the presence of extrapyramidal symptoms (more specifically dystonia of the lower limbs) and the genotype SCA2. The total number of non-ataxia symptoms and longer disease duration were independently associated with a higher fall frequency in a logistic regression analysis, while the presence of extrapyramidal symptoms was independently associated with a lower fall frequency. Our findings indicate that, in addition to more obvious factors that are associated with frequent falls, such as disease duration and ataxia severity, non-ataxia manifestations in SCA play a major role in the fall etiology of these patients.

Original languageEnglish
Pages (from-to)232-239
Number of pages8
Issue number2
Publication statusPublished - jún. 2010


ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Fonteyn, E. M. R., Schmitz-Hübsch, T., Verstappen, C. C., Baliko, L., Bloem, B. R., Boesch, S., Bunn, L., Charles, P., Dürr, A., Filla, A., Giunti, P., Globas, C., Klockgether, T., Melegh, B., Pandolfo, M., De Rosa, A., Schöls, L., Timmann, D., Munneke, M., ... Van De Warrenburg, B. P. C. (2010). Falls in spinocerebellar ataxias: Results of the EuroSCA fall study. Cerebellum, 9(2), 232-239. https://doi.org/10.1007/s12311-010-0155-z