Failed surgery for temporal lobe epilepsy: Predictors of long-term seizure-free course

J. Janszky, H. W. Pannek, I. Janszky, R. Schulz, F. Behne, M. Hoppe, A. Ebner

Research output: Article

49 Citations (Scopus)

Abstract

Objectives: To identify prognostic factors which predict the outcome 2 years after TLE surgery in those patients who were not seizure-free at the 6-month postoperative examination. Methods: We included 86 postoperative TLE patients who had undergone presurgical evaluation, including video-EEG and high-resolution MRI, and who had seizures between the second and sixth postoperative months. Results: 32% of patients were seizure-free in the second postoperative year. We found that normal MRI findings and secondarily generalized seizures (SGTCS) preoperatively were associated with a non-seizure-free outcome, while rare postoperative seizures and ipsilateral temporal IED with seizure-free outcome. Newly administered levetiracetam showed a significant positive effect on the postoperative outcome independent of other prognostic factors. Five of seven patients who received levetiracetam became seizure-free (p = 0.006). Conclusion: One-third of patients who did not become seizure-free immediately after surgery, eventually achieved long-term seizure freedom. We suggest watching for long-term seizure freedom after failed epilepsy surgery especially in patients who had rare postoperative seizures, focal MRI abnormality, ipsilateral temporal spikes, or no SGTCS preoperatively. Levetiracetam may have a positive effect on postsurgical seizures.

Original languageEnglish
Pages (from-to)35-44
Number of pages10
JournalEpilepsy Research
Volume64
Issue number1-2
DOIs
Publication statusPublished - márc. 2005

Fingerprint

Temporal Lobe Epilepsy
Seizures
etiracetam
Electroencephalography
Epilepsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology

Cite this

Failed surgery for temporal lobe epilepsy : Predictors of long-term seizure-free course. / Janszky, J.; Pannek, H. W.; Janszky, I.; Schulz, R.; Behne, F.; Hoppe, M.; Ebner, A.

In: Epilepsy Research, Vol. 64, No. 1-2, 03.2005, p. 35-44.

Research output: Article

Janszky, J, Pannek, HW, Janszky, I, Schulz, R, Behne, F, Hoppe, M & Ebner, A 2005, 'Failed surgery for temporal lobe epilepsy: Predictors of long-term seizure-free course', Epilepsy Research, vol. 64, no. 1-2, pp. 35-44. https://doi.org/10.1016/j.eplepsyres.2005.02.004
Janszky, J. ; Pannek, H. W. ; Janszky, I. ; Schulz, R. ; Behne, F. ; Hoppe, M. ; Ebner, A. / Failed surgery for temporal lobe epilepsy : Predictors of long-term seizure-free course. In: Epilepsy Research. 2005 ; Vol. 64, No. 1-2. pp. 35-44.
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