Terhességi és gyermekágyi thrombosis kockázatát befolyásoló tényezok faktor V Leiden-hordozók körében: Szelektív profîlaxis indikációi

Tünde Herman, Szilvia Vad, Éva Ajzner, István Balogh, Zoltán Boda, György Pfliegler, Róbert Póka

Research output: Review article

Abstract

In a retrospective controlled study the authors analysed the factors effecting the risk of pregnancy-associated thrombosis among factor V Leiden (FVL) carriers. They collected data regarding pregnancies, deliveries, thrombosis prophylaxis and history of thromboembolism from pregnancies of factor V Leiden carriers. Factors effecting pregnancy-associated thrombosis risk were identified in a logistic regression model. Two-hundred out of 301 pregnancies ended in childbirth and 40 were miscarriages. 25 cases had deep vein thrombosis (DVT). History of DVT was present in 36 pregnancies and there were 43 pregnancies with combined thrombophilia. Pregnancy-associated DVT in FVL carriers was closely related to the presence of combined thrombophilia (p=0.0001). In the logistic regression model, factors effecting the risk of thrombosis in FVL carrier pregnant women included: gestational age (OR=1.058, p=0.0089), the use of heparin prophylaxis (OR=0.118, p=0.0227) and the presence of combined thrombosis prophylaxis among FVL carrier pregnant women could be the history of DVT and the presence of combined thrombophilia.

Translated title of the contributionFactors effecting pregnancy-associated thrombosis risk among factor V Leiden carriers: Indications for selective prophylaxis
Original languageHungarian
Pages (from-to)299-305
Number of pages7
JournalMagyar Noorvosok Lapja
Volume67
Issue number5
Publication statusPublished - okt. 22 2004

Keywords

  • Leiden-mutation
  • Pregnancy
  • Thrombosis

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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