In a retrospective controlled study the authors analysed the factors effecting the risk of pregnancy-associated thrombosis among factor V Leiden (FVL) carriers. They collected data regarding pregnancies, deliveries, thrombosis prophylaxis and history of thromboembolism from pregnancies of factor V Leiden carriers. Factors effecting pregnancy-associated thrombosis risk were identified in a logistic regression model. Two-hundred out of 301 pregnancies ended in childbirth and 40 were miscarriages. 25 cases had deep vein thrombosis (DVT). History of DVT was present in 36 pregnancies and there were 43 pregnancies with combined thrombophilia. Pregnancy-associated DVT in FVL carriers was closely related to the presence of combined thrombophilia (p=0.0001). In the logistic regression model, factors effecting the risk of thrombosis in FVL carrier pregnant women included: gestational age (OR=1.058, p=0.0089), the use of heparin prophylaxis (OR=0.118, p=0.0227) and the presence of combined thrombosis prophylaxis among FVL carrier pregnant women could be the history of DVT and the presence of combined thrombophilia.
|Number of pages||7|
|Journal||Magyar Noorvosok Lapja|
|Publication status||Published - okt. 22 2004|
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynaecology