Factor V Leiden as a risk factor for miscarriage and reduced fertility

S. N. Baré, R. Póka, I. Balogh, É Ajzner

Research output: Article

30 Citations (Scopus)

Abstract

The Leiden mutation is a recent discovery. It is the main cause of inherited thrombophilia and has been found in 20-60% of deep vein thrombosis cases. More recently it has been found in a significant number of cases of obstetric complications attributable to placental thrombosis. Current patient management practice for dealing with the Leiden mutation is based mainly on information about deep vein thrombosis because there is little information on pregnancy complications. There are no prospective studies examining the risk of developing pregnancy complications for Leiden mutation carriers. The aim of this study is to do that by comparing the frequency of unfavourable pregnancy outcomes among carriers with those among controls. The number of women developing miscarriages, intrauterine deaths, or infertility problems among 128 Leiden mutation carriers was compared with the number among 461 controls. The risk of having at least one miscarriage or infertility problems was 1.5 times greater for Leiden mutation carriers than controls. This result was statistically significant (95% CI 1.2, 2.7). The risk of having at least hive miscarriages or infertility problems was 2.5 times greater for Leiden mutation carriers than controls. This was also statistically significant(95% CI 1.2, 5.13).

Original languageEnglish
Pages (from-to)186-190
Number of pages5
JournalAustralian and New Zealand Journal of Obstetrics and Gynaecology
Volume40
Issue number2
DOIs
Publication statusPublished - máj. 2000

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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