Facile synthesis of unsymmetrical 1,n′-disubstituted ferrocenoyl amino acid derivatives by palladium-catalyzed aminocarbonylation

Árpád Kuik, R. Skoda-Földes, László Jánosi, L. Kollár

Research output: Article

9 Citations (Scopus)

Abstract

Various unsymmetrical 1,n′-disubstituted ferrocenoyl amino acids were obtained by palladium-catalyzed aminocarbonylation starting from 1,1′-diiodoferrocene. The reactions were carried out in one-pot, using an equimolar mixture of two amino acid esters as nucleophiles. The structures of the products were determined by 1H NMR, 13C NMR, IR and MS analyses. Each was found to adopt an ordered, intramolecularly hydrogen bonded conformation.

Original languageEnglish
Pages (from-to)1456-1458
Number of pages3
JournalSynthesis
Issue number10
DOIs
Publication statusPublished - máj. 16 2007

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Palladium
Amino acids
Nuclear magnetic resonance
Derivatives
Amino Acids
Nucleophiles
Conformations
Hydrogen
Esters

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

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title = "Facile synthesis of unsymmetrical 1,n′-disubstituted ferrocenoyl amino acid derivatives by palladium-catalyzed aminocarbonylation",
abstract = "Various unsymmetrical 1,n′-disubstituted ferrocenoyl amino acids were obtained by palladium-catalyzed aminocarbonylation starting from 1,1′-diiodoferrocene. The reactions were carried out in one-pot, using an equimolar mixture of two amino acid esters as nucleophiles. The structures of the products were determined by 1H NMR, 13C NMR, IR and MS analyses. Each was found to adopt an ordered, intramolecularly hydrogen bonded conformation.",
keywords = "Amino acids, Carbonylations, Ferrocene, Homogeneous catalysis, Palladium",
author = "{\'A}rp{\'a}d Kuik and R. Skoda-F{\"o}ldes and L{\'a}szl{\'o} J{\'a}nosi and L. Koll{\'a}r",
year = "2007",
month = "5",
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language = "English",
pages = "1456--1458",
journal = "Synthesis",
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T1 - Facile synthesis of unsymmetrical 1,n′-disubstituted ferrocenoyl amino acid derivatives by palladium-catalyzed aminocarbonylation

AU - Kuik, Árpád

AU - Skoda-Földes, R.

AU - Jánosi, László

AU - Kollár, L.

PY - 2007/5/16

Y1 - 2007/5/16

N2 - Various unsymmetrical 1,n′-disubstituted ferrocenoyl amino acids were obtained by palladium-catalyzed aminocarbonylation starting from 1,1′-diiodoferrocene. The reactions were carried out in one-pot, using an equimolar mixture of two amino acid esters as nucleophiles. The structures of the products were determined by 1H NMR, 13C NMR, IR and MS analyses. Each was found to adopt an ordered, intramolecularly hydrogen bonded conformation.

AB - Various unsymmetrical 1,n′-disubstituted ferrocenoyl amino acids were obtained by palladium-catalyzed aminocarbonylation starting from 1,1′-diiodoferrocene. The reactions were carried out in one-pot, using an equimolar mixture of two amino acid esters as nucleophiles. The structures of the products were determined by 1H NMR, 13C NMR, IR and MS analyses. Each was found to adopt an ordered, intramolecularly hydrogen bonded conformation.

KW - Amino acids

KW - Carbonylations

KW - Ferrocene

KW - Homogeneous catalysis

KW - Palladium

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U2 - 10.1055/s-2007-966036

DO - 10.1055/s-2007-966036

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EP - 1458

JO - Synthesis

JF - Synthesis

SN - 0039-7881

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