EZH2 is a sensitive marker of malignancy in salivary gland tumors

Szofia Hajósi-Kalcakosz, Eszter Vincze, Katalin Dezso, Sándor Paku, András Rókusz, Zoltán Sápi, Erika Tóth, Péter Nagy

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Abstract

Background: The immunohistochemical detection of Enhancer of zeste homologue 2 (EZH2) proved to be a useful tool to recognize the malignant nature of tumors in a wide variety of neoplasms. The histological diagnostics of salivary gland tumors is a challenging task, and a reliable marker of malignancy would be extremely helpful. Methods: EZH2 expression was investigated in 54 malignant and 40 benign salivary gland tumors of various histological types by standard immunohistochemistry. Results: The majority (n = 52) of the malignant tumors stained positively, while all the investigated benign tumors were negative for EZH2. Conclusions: EZH2 expression in salivary gland tumors, similarly to the tumors of other organs is not characteristic for any tumor type, but is a solid marker of the malignant nature of the tumors.

Original languageEnglish
Article number163
JournalDiagnostic Pathology
Volume10
Issue number1
DOIs
Publication statusPublished - szept. 17 2015

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ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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