Expression of the neonatal Fc receptor (FcRn) in the bovine mammary gland

B. Mayer, Márton Doleschall, Balázs Bender, János Bartyik, Z. Bösze, L. Frenyó, I. Kacskovics

Research output: Article

45 Citations (Scopus)

Abstract

In ruminants, protective immunoglobulins are transferred to the newborn via colostrum to mediate maternal immunity. There is a high selectivity in the transport of immunoglobulins from the maternal plasma across the mammary barrier into the colostrum, and only IgG1 is transferred in large amounts. We have recently analysed the expression of the neonatal Fc receptor (FcRn) in sheep mammary gland around parturition. Re-analysing this issue in bovine confirmed our previous data indicating that FcRn is homogeneously localized in the mammary gland acinar cells before parturition, however a remarkable difference was observed in the pattern after calving, where only the apical side of the cells was strongly stained. The presence of the FcRn in the acinar epithelial cells of the mammary gland and the obvious change in distribution before and after parturition indicate that FcRn plays an important role in the IgG transport during colostrum formation in ruminants.

Original languageEnglish
Pages (from-to)107-112
Number of pages6
JournalJournal of Dairy Research
Volume72
Issue numberSPEC. ISS.
DOIs
Publication statusPublished - 2005

Fingerprint

Colostrum
Human Mammary Glands
colostrum
mammary glands
acinar cells
Acinar Cells
Ruminants
Parturition
parturition
immunoglobulins
receptors
Immunoglobulins
cattle
ruminants
Immunoglobulin G
Mothers
maternal immunity
breasts
calving
Immunity

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Applied Microbiology and Biotechnology
  • Food Science

Cite this

Expression of the neonatal Fc receptor (FcRn) in the bovine mammary gland. / Mayer, B.; Doleschall, Márton; Bender, Balázs; Bartyik, János; Bösze, Z.; Frenyó, L.; Kacskovics, I.

In: Journal of Dairy Research, Vol. 72, No. SPEC. ISS., 2005, p. 107-112.

Research output: Article

Mayer, B. ; Doleschall, Márton ; Bender, Balázs ; Bartyik, János ; Bösze, Z. ; Frenyó, L. ; Kacskovics, I. / Expression of the neonatal Fc receptor (FcRn) in the bovine mammary gland. In: Journal of Dairy Research. 2005 ; Vol. 72, No. SPEC. ISS. pp. 107-112.
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AU - Mayer, B.

AU - Doleschall, Márton

AU - Bender, Balázs

AU - Bartyik, János

AU - Bösze, Z.

AU - Frenyó, L.

AU - Kacskovics, I.

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