Experimental fluorosis in rats: NaF induced changes of bone and bone marrow

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3 Citations (Scopus)


According to recent studies, excess fluoride intake can cause both osteosclerosis and osteoporosis. The effect of fluoride can be influenced by several factors. In our experiments the aim was to demonstrate the alterations in bone and bone marrow caused by sodium fluoride, and to define the relation between the bone lesion and fluoride dosage. Of 20 white female rats, body weight 200 gr., 10 were administered 0.5 mg NaF, the other 10, 5 mg intraperitoneally for two months. NaF-induced bone changes were analyzed on ribs, vertebrae and femur. The decalcinated specimens were fixed in 8% neutral formalin, imbedded in paraffin, serially sectioned and stained with HE, or investigated by polarization optic methods. Bone and bone marrow alterations were evaluated by the morphometric method.

Original languageEnglish
Pages (from-to)106-111
Number of pages6
JournalFluoride - Quarterly Reports
Issue number2
Publication statusPublished - jan. 1 1983


ASJC Scopus subject areas

  • Biochemistry
  • Chemistry(all)
  • Dentistry(all)
  • Toxicology
  • Agricultural and Biological Sciences(all)
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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