Fever is a centrally regulated thermoregulatory response leading to a rise of body core temperature. The present review first summarizes alterations in autonomic and behavioral effector mechanisms that allow increases in heat production and/or in heat conservation observed in humans or in animals during natural fever. Experimental animal models have proved to be indispensable in deciphering the role of mediators acting in the CNS for the initiation of fever response. After briefly mentioning the importance of well established non-peptide mediators (e.g. prostaglandins) in fever genesis, data supporting the role of cytokines as endogenous pyrogens are listed. Based on experimental studies carried out mainly in small rodents a more detailed discussion of some centrally acting neuropeptide mediators supposed to play at least a partial role in the initiation of fever will follow. Along these lines, the central mediator role of neuropeptides such as substance P, cholecystokinin and ciliary neurotrophic factor will be discussed. Finally, an attempt is made to place the actions of these neuropeptide mediators in the hierarchy of heat generating and/or heat conserving mechanisms subserving fever genesis.
|Title of host publication||Fevers|
|Subtitle of host publication||Types, Treatments and Health Risks|
|Publisher||Nova Science Publishers, Inc.|
|Number of pages||11|
|Publication status||Published - márc. 1 2013|
ASJC Scopus subject areas