Experimental fever: The role of centrally acting neuropeptide mediators

Zoltán Szelényi, Margit Solymár

Research output: Chapter


Fever is a centrally regulated thermoregulatory response leading to a rise of body core temperature. The present review first summarizes alterations in autonomic and behavioral effector mechanisms that allow increases in heat production and/or in heat conservation observed in humans or in animals during natural fever. Experimental animal models have proved to be indispensable in deciphering the role of mediators acting in the CNS for the initiation of fever response. After briefly mentioning the importance of well established non-peptide mediators (e.g. prostaglandins) in fever genesis, data supporting the role of cytokines as endogenous pyrogens are listed. Based on experimental studies carried out mainly in small rodents a more detailed discussion of some centrally acting neuropeptide mediators supposed to play at least a partial role in the initiation of fever will follow. Along these lines, the central mediator role of neuropeptides such as substance P, cholecystokinin and ciliary neurotrophic factor will be discussed. Finally, an attempt is made to place the actions of these neuropeptide mediators in the hierarchy of heat generating and/or heat conserving mechanisms subserving fever genesis.

Original languageEnglish
Title of host publicationFevers
Subtitle of host publicationTypes, Treatments and Health Risks
PublisherNova Science Publishers, Inc.
Number of pages11
ISBN (Print)9781624177989
Publication statusPublished - márc. 1 2013

ASJC Scopus subject areas

  • Medicine(all)

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    Szelényi, Z., & Solymár, M. (2013). Experimental fever: The role of centrally acting neuropeptide mediators. In Fevers: Types, Treatments and Health Risks (pp. 63-73). Nova Science Publishers, Inc..