Exosomes in colorectal carcinoma formation: ALIX under the magnifying glass

Gábor Valcz, O. Galamb, T. Krenács, S. Spisák, Alexandra Kalmár, Árpád V. Patai, Barna Wichmann, Kristóf Dede, Z. Tulassay, B. Molnár

Research output: Article

10 Citations (Scopus)

Abstract

Exosomes are small membrane vesicles that have important roles in transporting a great variety of bioactive molecules between epithelial compartment and their microenvironment during tumor formation including colorectal adenoma–carcinoma sequence. We tested the mRNA expression of the top 25 exosome-related markers based on ExoCharta database in healthy (n=49), adenoma (n=49) and colorectal carcinoma (n=49) patients using Affymetrix HGU133 Plus2.0 microarrays. Most related genes showed significantly elevated expression including PGK1, PKM, ANXA5, ENO1, HSP90AB1 and MSN during adenoma–carcinoma sequence. Surprisingly, the expression of ALIX (ALG 2-interacting protein X), involved in multivesicular body (MVB) and exosome formation, was significantly reduced in normal vs adenoma (P=5.02 × 10-13) and in normal vs colorectal carcinoma comparisons (P=1.51 × 10-10). ALIX also showed significant reduction (P

Original languageEnglish
JournalModern Pathology
DOIs
Publication statusAccepted/In press - máj. 6 2016

Fingerprint

Exosomes
Glass
Colorectal Neoplasms
Adenoma
Multivesicular Bodies
Proteins
Tumor Microenvironment
Databases
Messenger RNA
Membranes
Genes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Exosomes in colorectal carcinoma formation : ALIX under the magnifying glass. / Valcz, Gábor; Galamb, O.; Krenács, T.; Spisák, S.; Kalmár, Alexandra; Patai, Árpád V.; Wichmann, Barna; Dede, Kristóf; Tulassay, Z.; Molnár, B.

In: Modern Pathology, 06.05.2016.

Research output: Article

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AU - Kalmár, Alexandra

AU - Patai, Árpád V.

AU - Wichmann, Barna

AU - Dede, Kristóf

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