A P-53 EXPRESSZIO VIZSGALATA GERMINALIS SEJTES HERERAKOKBAN

E. Hanna, E. Institoris, I. Bodrogi, J. Kondas, M. Bak

Research output: Article

Abstract

One of the most common cellular gene which negatively regulates the cell cycle, thus functioning as tumour suppressor gene, is the p-53 gene. The presence of this mutated gene has been correlated with the aggressiveness of several malignant neoplasmas. Expression of the p-53 gene product protein was screened in 55 untreated human germ cell testicular tumours, furthermore a relationship between p-53 expression and histology, and clinical stage was investigated. Using monoclonal antibody and immunoenzyme staining elevated p-53 level could be demonstrated in nuclei of embryonal carcinoma (84%) and seminoma components (56%). Most of the choriocarcinoma cases showed positive staining. Teratomas expressed this antigen negatively or scarcely. In seminomas the highest level of p-53 was stated in stage I. In contrast the opposite tendency could be demonstrated in embryonal carcinomas where p-53 was positive in stage III.

Translated title of the contributionExamination of p-53 expression in germ cell testicular cancer
Original languageHungarian
Pages (from-to)309-315
Number of pages7
JournalMagyar Urologia
Volume8
Issue number4
Publication statusPublished - dec. 1 1996

Keywords

  • Germ cell testicular cancer
  • P-53 expression

ASJC Scopus subject areas

  • Urology

Fingerprint Dive into the research topics of 'A P-53 EXPRESSZIO VIZSGALATA GERMINALIS SEJTES HERERAKOKBAN'. Together they form a unique fingerprint.

  • Cite this