Evidence for the Stereoelectronic Control of the Acid Hydrolysis of Adenosine Cyclic 3‘,5’-Phosphoramidate Diasteredisomers

S. Bottka, L. Radies, J. Tomasz

Research output: Article

4 Citations (Scopus)


The substitution by a methyl group of the axial 5'hydrogen atom of adenosine cyclic 3’,51-phosphoramidate diastereoisomers significantly increases the P-N bond breaking for the Rp diastereoisomer, but does not change that for the Sp diastereoisomer as anticipated on the basis of ground state stereoelectronic effects.

Original languageEnglish
Pages (from-to)1217-1229
Number of pages13
JournalNucleosides and Nucleotides
Issue number7
Publication statusPublished - jan. 1989


ASJC Scopus subject areas

  • Biochemistry
  • Genetics

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